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Literature summary extracted from

  • Murphy-Benenato, K.; Wang, H.; McGuire, H.M.; Davis, H.E.; Gao, N.; Prince, D.B.; Jahic, H.; Stokes, S.S.; Boriack-Sjodin, P.A.
    Identification through structure-based methods of a bacterial NAD(+)-dependent DNA ligase inhibitor that avoids known resistance mutations (2014), Bioorg. Med. Chem. Lett., 24, 360-366.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.5.1.2 (2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
-
 Enterococcus faecalis
6.5.1.2 (2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
-
 Haemophilus influenzae
6.5.1.2 (2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
-
 Staphylococcus aureus
6.5.1.2 (2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
-
 Streptococcus pneumoniae
6.5.1.2 2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
-
 Enterococcus faecalis
6.5.1.2 2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
-
 Haemophilus influenzae
6.5.1.2 2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
-
 Staphylococcus aureus
6.5.1.2 2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
-
 Streptococcus pneumoniae
6.5.1.2 2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
-
 Enterococcus faecalis
6.5.1.2 2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
-
 Haemophilus influenzae
6.5.1.2 2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
-
 Staphylococcus aureus
6.5.1.2 2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
-
 Streptococcus pneumoniae
6.5.1.2 2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
-
 Enterococcus faecalis
6.5.1.2 2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
-
 Haemophilus influenzae
6.5.1.2 2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
-
 Staphylococcus aureus
6.5.1.2 2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
-
 Streptococcus pneumoniae
6.5.1.2 4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
 Enterococcus faecalis
6.5.1.2 4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
 Haemophilus influenzae
6.5.1.2 4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
 Staphylococcus aureus
6.5.1.2 4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
 Streptococcus pneumoniae
6.5.1.2 4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
 Enterococcus faecalis
6.5.1.2 4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
 Haemophilus influenzae
6.5.1.2 4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
 Staphylococcus aureus
6.5.1.2 4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
 Streptococcus pneumoniae
6.5.1.2 4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
-
 Enterococcus faecalis
6.5.1.2 4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
-
 Haemophilus influenzae
6.5.1.2 4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
-
 Staphylococcus aureus
6.5.1.2 4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
-
 Streptococcus pneumoniae
6.5.1.2 4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
-
 Enterococcus faecalis
6.5.1.2 4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
-
 Haemophilus influenzae
6.5.1.2 4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
-
 Staphylococcus aureus
6.5.1.2 4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
-
 Streptococcus pneumoniae
6.5.1.2 4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
 Enterococcus faecalis
6.5.1.2 4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
 Haemophilus influenzae
6.5.1.2 4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
 Staphylococcus aureus
6.5.1.2 4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
 Streptococcus pneumoniae
6.5.1.2 4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
-
 Enterococcus faecalis
6.5.1.2 4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
-
 Haemophilus influenzae
6.5.1.2 4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
-
 Staphylococcus aureus
6.5.1.2 4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
-
 Streptococcus pneumoniae
6.5.1.2 4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
 Enterococcus faecalis
6.5.1.2 4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
 Haemophilus influenzae
6.5.1.2 4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
 Staphylococcus aureus
6.5.1.2 4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
 Streptococcus pneumoniae
6.5.1.2 4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
-
 Enterococcus faecalis
6.5.1.2 4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
-
 Haemophilus influenzae
6.5.1.2 4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
-
 Staphylococcus aureus
6.5.1.2 4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
-
 Streptococcus pneumoniae
6.5.1.2 4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
-
 Enterococcus faecalis
6.5.1.2 4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
-
 Haemophilus influenzae
6.5.1.2 4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
-
 Staphylococcus aureus
6.5.1.2 4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
-
 Streptococcus pneumoniae
6.5.1.2 4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
-
 Enterococcus faecalis
6.5.1.2 4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
-
 Haemophilus influenzae
6.5.1.2 4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
-
 Staphylococcus aureus
6.5.1.2 4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
-
 Streptococcus pneumoniae
6.5.1.2 4-aminothieno[3,2-c]pyridine-7-carboxamide
-
 Enterococcus faecalis
6.5.1.2 4-aminothieno[3,2-c]pyridine-7-carboxamide
-
 Haemophilus influenzae
6.5.1.2 4-aminothieno[3,2-c]pyridine-7-carboxamide
-
 Staphylococcus aureus
6.5.1.2 4-aminothieno[3,2-c]pyridine-7-carboxamide
-
 Streptococcus pneumoniae
6.5.1.2 ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
-
 Enterococcus faecalis
6.5.1.2 ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
-
 Haemophilus influenzae
6.5.1.2 ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
-
 Staphylococcus aureus
6.5.1.2 ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
-
 Streptococcus pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.2 Enterococcus faecalis
-
-
-
6.5.1.2 Haemophilus influenzae
-
-
-
6.5.1.2 Staphylococcus aureus
-
-
-
6.5.1.2 Streptococcus pneumoniae
-
-
-

Synonyms

EC Number Synonyms Comment Organism
6.5.1.2 LigA
-
 Staphylococcus aureus
6.5.1.2 LigA
-
 Haemophilus influenzae
6.5.1.2 LigA
-
 Enterococcus faecalis
6.5.1.2 LigA
-
 Streptococcus pneumoniae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.5.1.2 0.00021
-
 pH and temperature not specified in the publication Streptococcus pneumoniae (2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
6.5.1.2 0.00043
-
 pH and temperature not specified in the publication Staphylococcus aureus (2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
6.5.1.2 0.00051
-
 pH and temperature not specified in the publication Haemophilus influenzae (2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
6.5.1.2 0.003
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.0071
-
 pH and temperature not specified in the publication Staphylococcus aureus 4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.0081
-
 pH and temperature not specified in the publication Enterococcus faecalis 4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.0089
-
 pH and temperature not specified in the publication Staphylococcus aureus ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
6.5.1.2 0.0094
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
6.5.1.2 0.0094
-
 pH and temperature not specified in the publication Streptococcus pneumoniae ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
6.5.1.2 0.015
-
 pH and temperature not specified in the publication Staphylococcus aureus 4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
6.5.1.2 0.021
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.025
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 4-aminothieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.029
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.034
-
 pH and temperature not specified in the publication Enterococcus faecalis 4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
6.5.1.2 0.036
-
 pH and temperature not specified in the publication Staphylococcus aureus 4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.036
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.039
-
 pH and temperature not specified in the publication Staphylococcus aureus 4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.048
-
 pH and temperature not specified in the publication Staphylococcus aureus 4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.052
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
6.5.1.2 0.069
-
 pH and temperature not specified in the publication Staphylococcus aureus 4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
6.5.1.2 0.074
-
 pH and temperature not specified in the publication Enterococcus faecalis ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
6.5.1.2 0.075
-
 pH and temperature not specified in the publication Staphylococcus aureus 4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
6.5.1.2 0.077
-
 pH and temperature not specified in the publication Enterococcus faecalis 4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.1
-
 pH and temperature not specified in the publication Enterococcus faecalis 4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.1
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.13
-
 pH and temperature not specified in the publication Enterococcus faecalis 4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.13
-
 pH and temperature not specified in the publication Enterococcus faecalis 2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.14
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
6.5.1.2 0.14
-
 value above, pH and temperature not specified in the publication Streptococcus pneumoniae 4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.15
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.15
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.16
-
 pH and temperature not specified in the publication Haemophilus influenzae 4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.16
-
 pH and temperature not specified in the publication Haemophilus influenzae 2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.16
-
 pH and temperature not specified in the publication Enterococcus faecalis 2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.18
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 pH and temperature not specified in the publication Haemophilus influenzae 2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Haemophilus influenzae 4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Staphylococcus aureus 4-aminothieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Haemophilus influenzae 4-aminothieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Enterococcus faecalis 4-aminothieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Staphylococcus aureus 4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Haemophilus influenzae 4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Enterococcus faecalis 4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Haemophilus influenzae 4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Haemophilus influenzae ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Haemophilus influenzae 4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Enterococcus faecalis 4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Haemophilus influenzae 4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Haemophilus influenzae 4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Staphylococcus aureus 4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Haemophilus influenzae 4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Enterococcus faecalis 4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Haemophilus influenzae 4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Enterococcus faecalis 4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Staphylococcus aureus 4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Haemophilus influenzae 4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Enterococcus faecalis 4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Streptococcus pneumoniae 2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Staphylococcus aureus 2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Haemophilus influenzae 2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Enterococcus faecalis 2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
6.5.1.2 0.2
-
 value above, pH and temperature not specified in the publication Streptococcus pneumoniae 2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide