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Literature summary extracted from
- Prohormone-substrate peptide sequence recognition by peptidylglycine alpha-amidating monooxygenase and its reflection in increased glycolate inhibitor potency (2012), Bioorg. Med. Chem. Lett., 22, 7015-7018.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.17.3 | (acetyloxy)acetic acid | - |
Homo sapiens |  |
| 1.14.17.3 | ([(2S)-2-[(2-aminopropanoyl)amino]-3-phenylpropanoyl]oxy)acetic acid | - |
Homo sapiens | |
| 1.14.17.3 | ([N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]-L-phenylalanyl]oxy)acetic acid | - |
Homo sapiens | |
| 1.14.17.3 | ([N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]glycyl]oxy)acetic acid | - |
Homo sapiens | |
| 1.14.17.3 | ([[(2S)-1-(2-aminopropanoyl)pyrrolidin-2-yl]carbonyl]oxy)acetic acid | - |
Homo sapiens | |
| 1.14.17.3 | ([[(2S)-1-[[(2-aminopropanoyl)amino]acetyl]pyrrolidin-2-yl]carbonyl]oxy)acetic acid | - |
Homo sapiens | |
| 1.14.17.3 | ([[(4-amino-6-methyl-3-oxoheptanoyl)amino]acetyl]oxy)acetic acid | - |
Homo sapiens | |
| 1.14.17.3 | [[(2S)-2-(acetylamino)-3-phenylpropanoyl]oxy]acetic acid | - |
Homo sapiens | |
| 1.14.17.3 | [[(2S)-2-([[(2-aminopropanoyl)amino]acetyl]amino)-3-phenylpropanoyl]oxy]acetic acid | - |
Homo sapiens | |
| 1.14.17.3 | [[(2S)-2-amino-3-phenylpropanoyl]oxy]acetic acid | - |
Homo sapiens | |
| 1.14.17.3 | [[(2S)-pyrrolidin-2-ylcarbonyl]oxy]acetic acid | - |
Homo sapiens | |
| 1.14.17.3 | [[(acetylamino)acetyl]oxy]acetic acid | - |
Homo sapiens | |
| 1.14.17.3 | [[N-(4-amino-6-methyl-3-oxoheptanoyl)-L-phenylalanyl]oxy]acetic acid | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.17.3 | 0.007 | - |
N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]-L-phenylalanylglycine | pH and temperature not specified in the publication | Homo sapiens | |
| 1.14.17.3 | 0.011 | - |
N-(4-amino-6-methyl-3-oxoheptanoyl)-L-phenylalanylglycine | pH and temperature not specified in the publication | Homo sapiens | |
| 1.14.17.3 | 0.016 | - |
N-acetyl-L-phenylalanylglycine | pH and temperature not specified in the publication | Homo sapiens | |
| 1.14.17.3 | 0.018 | - |
alanylglycylvalyl-L-phenylalanylglycine | pH and temperature not specified in the publication | Homo sapiens | |
| 1.14.17.3 | 0.035 | - |
alanylglycyl-L-phenylalanylglycine | pH and temperature not specified in the publication | Homo sapiens | |
| 1.14.17.3 | 0.2 | - |
alanyl-L-phenylalanylglycine | pH and temperature not specified in the publication | Homo sapiens | |
| 1.14.17.3 | 0.55 | - |
N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]glycylglycine | pH and temperature not specified in the publication | Homo sapiens | |
| 1.14.17.3 | 0.86 | - |
N-(4-amino-6-methyl-3-oxoheptanoyl)glycylglycine | pH and temperature not specified in the publication | Homo sapiens | |
| 1.14.17.3 | 0.88 | - |
L-prolylglycine | pH and temperature not specified in the publication | Homo sapiens | |
| 1.14.17.3 | 0.96 | - |
alanylglycylvalyl-L-prolylglycine | pH and temperature not specified in the publication | Homo sapiens | |
| 1.14.17.3 | 1.2 | - |
N-acetylglycylglycine | pH and temperature not specified in the publication | Homo sapiens | |
| 1.14.17.3 | 3 | - |
alanylglycyl-L-prolylglycine | pH and temperature not specified in the publication | Homo sapiens | |
| 1.14.17.3 | 4 | - |
alanyl-L-prolylglycine | pH and temperature not specified in the publication | Homo sapiens | |
| 1.14.17.3 | 6.5 | - |
L-phenylalanylglycine | pH and temperature not specified in the publication | Homo sapiens | |
| 1.14.17.3 | 9.9 | - |
N-acetylglycine | pH and temperature not specified in the publication | Homo sapiens | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.17.3 | Cu2+ | required for activity | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.17.3 | peptidylglycine + ascorbate + O2 | Homo sapiens | - |
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.17.3 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.17.3 | DMS-53 cell | - |
Homo sapiens | - |
| 1.14.17.3 | small cell lung cancer cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.17.3 | alanyl-L-phenylalanylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
| 1.14.17.3 | alanyl-L-prolylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
| 1.14.17.3 | alanylglycyl-L-phenylalanylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
| 1.14.17.3 | alanylglycyl-L-prolylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
| 1.14.17.3 | alanylglycylvalyl-L-phenylalanylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
| 1.14.17.3 | alanylglycylvalyl-L-prolylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
| 1.14.17.3 | L-phenylalanylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
| 1.14.17.3 | L-prolylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
| 1.14.17.3 | additional information | the enzyme peptidylglycine alpha-amidating monooxygenase consists of two subunits: peptidylglycine alpha-hydroxylating monooxygenase that initiates formation of a radical at a substrate's C-terminal glycine alpha-carbon to then give an alpha-hydroxylated glycine derivative, and peptidylamidoglycolate lyase which catalyzes cleavage of this hydroxyglycine intermediate to give the amidated product with consequent release of glyoxylate | Homo sapiens | ? | - |
? | |
| 1.14.17.3 | N-(4-amino-6-methyl-3-oxoheptanoyl)-L-phenylalanylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
| 1.14.17.3 | N-(4-amino-6-methyl-3-oxoheptanoyl)glycylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
| 1.14.17.3 | N-acetyl-L-phenylalanylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
| 1.14.17.3 | N-acetylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
| 1.14.17.3 | N-acetylglycylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
| 1.14.17.3 | N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]-L-phenylalanylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
| 1.14.17.3 | N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]glycylglycine + ascorbate + O2 | - |
Homo sapiens | ? + dehydroascorbate + H2O | - |
? | |
| 1.14.17.3 | peptidylglycine + ascorbate + O2 | - |
Homo sapiens | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.17.3 | PAM | - |
Homo sapiens |
| 1.14.17.3 | peptidylglycine alpha-amidating monooxygenase | - |
Homo sapiens |
| 1.14.17.3 | peptidylglycine alpha-hydroxylating monooxygenase | - |
Homo sapiens |
| 1.14.17.3 | PHM | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.17.3 | ascorbate | - |
Homo sapiens | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.14.17.3 | 0.009 | - |
pH and temperature not specified in the publication | Homo sapiens | [[N-(4-amino-6-methyl-3-oxoheptanoyl)-L-phenylalanyl]oxy]acetic acid | |
| 1.14.17.3 | 0.011 | - |
pH and temperature not specified in the publication | Homo sapiens | [[(2S)-2-(acetylamino)-3-phenylpropanoyl]oxy]acetic acid | |
| 1.14.17.3 | 0.038 | - |
pH and temperature not specified in the publication | Homo sapiens | ([N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]-L-phenylalanyl]oxy)acetic acid | |
| 1.14.17.3 | 0.16 | - |
pH and temperature not specified in the publication | Homo sapiens | [[(2S)-2-([[(2-aminopropanoyl)amino]acetyl]amino)-3-phenylpropanoyl]oxy]acetic acid | |
| 1.14.17.3 | 0.18 | - |
pH and temperature not specified in the publication | Homo sapiens | ([N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]glycyl]oxy)acetic acid | |
| 1.14.17.3 | 0.2 | - |
pH and temperature not specified in the publication | Homo sapiens | ([[(4-amino-6-methyl-3-oxoheptanoyl)amino]acetyl]oxy)acetic acid | |
| 1.14.17.3 | 0.29 | - |
pH and temperature not specified in the publication | Homo sapiens | ([[(2S)-1-(2-aminopropanoyl)pyrrolidin-2-yl]carbonyl]oxy)acetic acid | |
| 1.14.17.3 | 0.37 | - |
pH and temperature not specified in the publication | Homo sapiens | ([(2S)-2-[(2-aminopropanoyl)amino]-3-phenylpropanoyl]oxy)acetic acid | |
| 1.14.17.3 | 0.5 | - |
pH and temperature not specified in the publication | Homo sapiens | [[(2S)-pyrrolidin-2-ylcarbonyl]oxy]acetic acid | |
| 1.14.17.3 | 1.1 | - |
pH and temperature not specified in the publication | Homo sapiens | (acetyloxy)acetic acid | |
| 1.14.17.3 | 1.1 | - |
pH and temperature not specified in the publication | Homo sapiens | ([[(2S)-1-[[(2-aminopropanoyl)amino]acetyl]pyrrolidin-2-yl]carbonyl]oxy)acetic acid | |
| 1.14.17.3 | 1.6 | - |
pH and temperature not specified in the publication | Homo sapiens | [[(2S)-2-amino-3-phenylpropanoyl]oxy]acetic acid | |
| 1.14.17.3 | 1.8 | - |
pH and temperature not specified in the publication | Homo sapiens | [[(acetylamino)acetyl]oxy]acetic acid | |
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