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Literature summary extracted from

  • Kuwata, H.; Yoshimura, M.; Sasaki, Y.; Yoda, E.; Nakatani, Y.; Kudo, I.; Hara, S.
    Role of long-chain acyl-coenzyme A synthetases in the regulation of arachidonic acid metabolism in interleukin 1beta-stimulated rat fibroblasts (2014), Biochim. Biophys. Acta, 1841, 44-53.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.3 Triacsin C
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.3 ATP + arachidonate + CoA Rattus norvegicus preferred substrate AMP + diphosphate + arachidonoyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.3 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.3 3Y1 cell
-
 Rattus norvegicus
-
6.2.1.3 fibroblast
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.3 ATP + arachidonate + CoA preferred substrate Rattus norvegicus AMP + diphosphate + arachidonoyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.3 ACSL
-
 Rattus norvegicus
6.2.1.3 ACSL1 isoform Rattus norvegicus
6.2.1.3 ACSL3 isoform Rattus norvegicus
6.2.1.3 ACSL4 isoform Rattus norvegicus
6.2.1.3 Long-chain acyl-coenzyme A synthetase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.3 ATP
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
6.2.1.3 malfunction knockdown of endogenous Acsl4 expression increases significantly the release of arachidonate metabolites, including prostaglandin E2, prostaglandin D2, and prostaglandin F2alpha, compared with replicated control cells, whereas knockdown of Acsl1 expression reduces the interleukin-1beta-induced release of arachidonate metabolites Rattus norvegicus
6.2.1.3 physiological function Acsl isozymes play distinct roles in the control of arachidonate remodeling in rat fibroblasts: isoform Acsl4 acts as the first step of enzyme for arachidonate remodeling following interleukin-1beta stimulation, and isoform Acsl1 is involved in the maintenance of some arachidonate-containing phosphatidylcholine species Rattus norvegicus