Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Oliver, J.C.; Linger, R.S.; Chittur, S.V.; Davisson, V.J.
    Substrate activation and conformational dynamics of guanosine 5'-monophosphate synthetase (2013), Biochemistry, 52, 5225-5235.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.5.2 expressed in Escherichia coli DH5alpha cells Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
6.3.5.2 37W the mutant shows severely reduced specific activity compared to the wild type enzyme Escherichia coli
6.3.5.2 W37A the mutant shows slightly reduced specific activity compared to the wild type enzyme Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.5.2 XMP substrate inhibition above 0.2 mM Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.5.2 Mg2+ required Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.5.2 ATP + XMP + L-glutamine + H2O Escherichia coli
-
 AMP + diphosphate + GMP + L-glutamate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.5.2 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.5.2 ATP + XMP + L-glutamine + H2O
-
 Escherichia coli AMP + diphosphate + GMP + L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.5.2 GMP synthetase
-
 Escherichia coli
6.3.5.2 GMPS
-
 Escherichia coli
6.3.5.2 GuaA
-
 Escherichia coli
6.3.5.2 Guanosine 5'-monophosphate synthetase
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.5.2 ATP
-
 Escherichia coli