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Literature summary extracted from

  • Hassink, G.; Kikkert, M.; Van Voorden, S.; Lee, S.; Spaapen, R.; Van Laar, T.; Coleman, C.; Bartee, E.; Früh, K.; Chau, V.; Wiertz, E.
    TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum (2005), Biochem. J., 388, 647-655.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.2.27 expression in HeLa cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.2.27 C9A mutation within the RING domain of TEB4, strongly impairs its own degradation Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.27 endoplasmic reticulum
-
Homo sapiens 5783
-
2.3.2.27 membrane sequence contains 13 predicted transmembrane domains. The N-terminal region of TEB4 is located in the cytoplasm, whereas the C-terminus of TEB4 has a luminal deposition Homo sapiens 16020
-
2.3.2.27 additional information isoform TEB4 is notexpressed at the cell surface Homo sapiens
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.2.27 97000
-
x * 97000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.27 Homo sapiens O60337 isoform TEB4
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.27 [TEB4-UBC7]-S-ubiquitinyl-L-cysteine + ubiquitin-L-lysine48
-
Homo sapiens [TEB4-UBC7]-L-cysteine + ubiquitin-N6-ubiquitinyl-L-lysine48 formation of a ubiquitin dimer, where residue lysine48 is linked to the C-terminal carboxyl of another ubiquitin. The UBC7-dependent ubiquitin–ubiquitin linkage reaction requires the presence of the ubiquitin-activating enzyme E1 and ATP, suggesting that the activity requires the intermediate formation of an UBC7-ubiquitin thioester ?
2.3.2.27 [TEB4-UBC7]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine
-
Homo sapiens [TEB4-UBC7]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine the isolated TEB4 RING domain catalyses ubiquitin ligation in vitro in a reaction that is ubiquitin Lys48-specific and involves ubiquitin-conjugating enzyme UBC7 ?

Subunits

EC Number Subunits Comment Organism
2.3.2.27 ? x * 97000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.3.2.27 MARCH6
-
Homo sapiens
2.3.2.27 TEB4
-
Homo sapiens

Expression

EC Number Organism Comment Expression
2.3.2.27 Homo sapiens TEB4 expression does not increase in response to the various stress conditions additional information

General Information

EC Number General Information Comment Organism
2.3.2.27 metabolism isoform TEB4 is an ER degradation substrate itself, promoting its own degradation in a RING finger- and proteasome-dependent manner Homo sapiens