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Literature summary extracted from
- CO2 fixation for succinic acid production by engineered Escherichia coli co-expressing pyruvate carboxylase and nicotinic acid phosphoribosyltransferase (2013), Biochem. Eng. J., 79, 77-83.
No PubMed abstract available
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 6.3.4.21 | expressed in Escherichia coli strains BA002, BA014, BA026, and BA207 | Escherichia coli |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 6.3.4.21 | nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O | Escherichia coli | - |
beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 6.3.4.21 | Escherichia coli | - |
- |
- |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 6.3.4.21 | 0.7 | - |
recombinant enzyme from Escherichia coli strain BA002, pH and temperature not specified in the publication | Escherichia coli |
| 6.3.4.21 | 1.01 | - |
recombinant enzyme from Escherichia coli strain BA206, pH and temperature not specified in the publication | Escherichia coli |
| 6.3.4.21 | 10.54 | - |
recombinant enzyme from Escherichia coli strain BA014, pH and temperature not specified in the publication | Escherichia coli |
| 6.3.4.21 | 12.24 | - |
recombinant enzyme from Escherichia coli strain BA207, pH and temperature not specified in the publication | Escherichia coli |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 6.3.4.21 | nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O | - |
Escherichia coli | beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 6.3.4.21 | EC 2.4.2.11 | formerly | Escherichia coli |
| 6.3.4.21 | NAPRTase | - |
Escherichia coli |
| 6.3.4.21 | nicotinic acid phosphoribosyltransferase | - |
Escherichia coli |
| 6.3.4.21 | pncB | - |
Escherichia coli |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 6.3.4.21 | ATP | - |
Escherichia coli | |
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Release 2023.1 (January 2023)
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