BRENDA - Enzyme Database

Ubiquitous distribution of phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase in bacteria and archaea, which contain inositol phospholipid

Morii, H.; Ogawa, M.; Fukuda, K.; Taniguchi, H.; Biochem. Biophys. Res. Commun. 443, 86-90 (2013)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
2.7.8.39
expression in Escherichia coli
Aeropyrum pernix
2.7.8.39
expression in Escherichia coli
Saccharolobus solfataricus
Engineering
EC Number
Amino acid exchange
Commentary
Organism
2.7.8.11
additional information
an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Homo sapiens cells. The recombinant cells do not show phosphatidylinositol phosphate synthase or archaetidylinositol phosphate synthase activities. Phosphatidylinositol synthase and archaetidylinositol synthase activities are determined, 7 pmol/h/mg and 2 pmol/h/mg, respectively
Homo sapiens
2.7.8.11
additional information
an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Saccharomyces cerevisiae cells. The recombinant cells do not show phosphatidylinositol phosphate synthase or archaetidylinositol phosphate synthase activities. Phosphatidylinositol synthase and archaetidylinositol synthase activities are determined, 107 pmol/h/mg and 7 pmol/h/mg, respectively
Saccharomyces cerevisiae
2.7.8.B13
additional information
an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Corynebacterium glutamicum cells. The recombinant cells show afterwards both, phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase activities, 175 pmol/h/mg and 174 pmol/h/mg, respectively, but no phosphatidylinositol synthase activity is detected, overview
Corynebacterium glutamicum
2.7.8.B13
additional information
an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Propionibacterium acnes cells. The recombinant cells show afterwards both, phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase activities, 88 pmol/h/mg and 14 pmol/h/mg, respectively, but no phosphatidylinositol synthase activity is detected, overview
Cutibacterium acnes
2.7.8.B13
additional information
an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Mycobacterium bovis cells. The recombinant cells show afterwards both, phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase activities, 138 pmol/h/mg and 5 pmol/h/mg, respectively, but no phosphatidylinositol synthase activity is detected, overview
Mycobacterium tuberculosis variant bovis
2.7.8.B13
additional information
an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Rhodococcus equi cells. The recombinant cells show afterwards both, phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase activities, 124 pmol/h/mg and 33 pmol/h/mg, respectively, but no phosphatidylinositol synthase activity is detected, overview
Rhodococcus hoagii
2.7.8.B13
additional information
an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Streptomyces avermitilis cells. The recombinant cells show afterwards both, phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase activities, 76 pmol/h/mg and 20 pmol/h/mg, respectively, but no phosphatidylinositol synthase activity is detected, overview
Streptomyces avermitilis
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.8.11
Mn2+
required
Homo sapiens
2.7.8.11
Mn2+
required
Saccharomyces cerevisiae
2.7.8.B13
Mg2+
required
Corynebacterium glutamicum
2.7.8.B13
Mg2+
required
Cutibacterium acnes
2.7.8.B13
Mg2+
required
Rhodococcus hoagii
2.7.8.B13
Mg2+
required
Streptomyces avermitilis
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.8.11
CDP-diacylglycerol + myo-inositol
Homo sapiens
-
CMP + 1-phosphatidyl-1D-myo-inositol
-
-
?
2.7.8.11
CDP-diacylglycerol + myo-inositol
Saccharomyces cerevisiae
-
CMP + 1-phosphatidyl-1D-myo-inositol
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
Corynebacterium glutamicum
specificity of PIP synthase for lipid substrates
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
Rhodococcus hoagii
specificity of PIP synthase for lipid substrates
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
Mycobacterium tuberculosis variant bovis
specificity of PIP synthase for lipid substrates
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
Cutibacterium acnes
specificity of PIP synthase for lipid substrates
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
Streptomyces avermitilis
specificity of PIP synthase for lipid substrates
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.8.11
Homo sapiens
-
-
-
2.7.8.11
Saccharomyces cerevisiae
P70500
-
-
2.7.8.B13
Corynebacterium glutamicum
-
-
-
2.7.8.B13
Cutibacterium acnes
-
-
-
2.7.8.B13
Mycobacterium tuberculosis variant bovis
-
-
-
2.7.8.B13
Rhodococcus hoagii
-
-
-
2.7.8.B13
Streptomyces avermitilis
-
-
-
2.7.8.39
Aeropyrum pernix
Q9YBS3
-
-
2.7.8.39
Aeropyrum pernix DSM 11879
Q9YBS3
-
-
2.7.8.39
Saccharolobus solfataricus
Q7LXU6
-
-
2.7.8.39
Saccharolobus solfataricus P2
Q7LXU6
-
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.7.8.39
1783
-
pH 6.0, 80°C
Saccharolobus solfataricus
2.7.8.39
1867
-
pH 6.0, 80°C
Aeropyrum pernix
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.8.11
CDP-diacylglycerol + myo-inositol
-
726887
Homo sapiens
CMP + 1-phosphatidyl-1D-myo-inositol
-
-
-
?
2.7.8.11
CDP-diacylglycerol + myo-inositol
-
726887
Saccharomyces cerevisiae
CMP + 1-phosphatidyl-1D-myo-inositol
-
-
-
?
2.7.8.11
CDP-diacylglycerol + myo-inositol
specificity of PI synthase for the substrates, no activity with 1L-myo-inositol 1-phosphate
726887
Homo sapiens
CMP + 1-phosphatidyl-1D-myo-inositol
-
-
-
?
2.7.8.11
CDP-diacylglycerol + myo-inositol
specificity of PI synthase for the substrates, no activity with 1L-myo-inositol 1-phosphate
726887
Saccharomyces cerevisiae
CMP + 1-phosphatidyl-1D-myo-inositol
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
-
726887
Corynebacterium glutamicum
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
-
726887
Rhodococcus hoagii
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
-
726887
Mycobacterium tuberculosis variant bovis
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
-
726887
Cutibacterium acnes
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
-
726887
Streptomyces avermitilis
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
specificity of PIP synthase for lipid substrates
726887
Corynebacterium glutamicum
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
specificity of PIP synthase for lipid substrates
726887
Rhodococcus hoagii
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
specificity of PIP synthase for lipid substrates
726887
Mycobacterium tuberculosis variant bovis
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
specificity of PIP synthase for lipid substrates
726887
Cutibacterium acnes
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
specificity of PIP synthase for lipid substrates
726887
Streptomyces avermitilis
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.39
CDP-2,3-bis-(O-phytanyl)-sn-glycerol + 1L-myo-inositol 1-phosphate
-
726887
Aeropyrum pernix
CMP + 1-archaetidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.39
CDP-2,3-bis-(O-phytanyl)-sn-glycerol + 1L-myo-inositol 1-phosphate
-
726887
Saccharolobus solfataricus
CMP + 1-archaetidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.39
CDP-2,3-bis-(O-phytanyl)-sn-glycerol + 1L-myo-inositol 1-phosphate
-
726887
Aeropyrum pernix DSM 11879
CMP + 1-archaetidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.39
CDP-2,3-bis-(O-phytanyl)-sn-glycerol + 1L-myo-inositol 1-phosphate
-
726887
Saccharolobus solfataricus P2
CMP + 1-archaetidyl-1D-myo-inositol 3-phosphate
-
-
-
?
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.7.8.11
30
-
assay at
Saccharomyces cerevisiae
2.7.8.11
37
-
assay at
Homo sapiens
2.7.8.B13
37
-
assay at
Corynebacterium glutamicum
2.7.8.B13
37
-
assay at
Cutibacterium acnes
2.7.8.B13
37
-
assay at
Rhodococcus hoagii
2.7.8.B13
37
-
assay at
Streptomyces avermitilis
2.7.8.39
80
-
assay at
Aeropyrum pernix
2.7.8.39
80
-
assay at
Saccharolobus solfataricus
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.7.8.11
8
-
assay at
Homo sapiens
2.7.8.11
8
-
assay at
Saccharomyces cerevisiae
2.7.8.B13
8
-
assay at
Corynebacterium glutamicum
2.7.8.B13
8
-
assay at
Cutibacterium acnes
2.7.8.B13
8
-
assay at
Rhodococcus hoagii
2.7.8.B13
8
-
assay at
Streptomyces avermitilis
2.7.8.39
6
-
assay at
Aeropyrum pernix
2.7.8.39
6
-
assay at
Saccharolobus solfataricus
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.7.8.39
expression in Escherichia coli
Aeropyrum pernix
2.7.8.39
expression in Escherichia coli
Saccharolobus solfataricus
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
2.7.8.11
additional information
an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Homo sapiens cells. The recombinant cells do not show phosphatidylinositol phosphate synthase or archaetidylinositol phosphate synthase activities. Phosphatidylinositol synthase and archaetidylinositol synthase activities are determined, 7 pmol/h/mg and 2 pmol/h/mg, respectively
Homo sapiens
2.7.8.11
additional information
an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Saccharomyces cerevisiae cells. The recombinant cells do not show phosphatidylinositol phosphate synthase or archaetidylinositol phosphate synthase activities. Phosphatidylinositol synthase and archaetidylinositol synthase activities are determined, 107 pmol/h/mg and 7 pmol/h/mg, respectively
Saccharomyces cerevisiae
2.7.8.B13
additional information
an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Corynebacterium glutamicum cells. The recombinant cells show afterwards both, phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase activities, 175 pmol/h/mg and 174 pmol/h/mg, respectively, but no phosphatidylinositol synthase activity is detected, overview
Corynebacterium glutamicum
2.7.8.B13
additional information
an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Propionibacterium acnes cells. The recombinant cells show afterwards both, phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase activities, 88 pmol/h/mg and 14 pmol/h/mg, respectively, but no phosphatidylinositol synthase activity is detected, overview
Cutibacterium acnes
2.7.8.B13
additional information
an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Mycobacterium bovis cells. The recombinant cells show afterwards both, phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase activities, 138 pmol/h/mg and 5 pmol/h/mg, respectively, but no phosphatidylinositol synthase activity is detected, overview
Mycobacterium tuberculosis variant bovis
2.7.8.B13
additional information
an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Rhodococcus equi cells. The recombinant cells show afterwards both, phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase activities, 124 pmol/h/mg and 33 pmol/h/mg, respectively, but no phosphatidylinositol synthase activity is detected, overview
Rhodococcus hoagii
2.7.8.B13
additional information
an artificial gene construct for a protein homologous to phosphatidylinositol phosphate synthase of Mycobacterium tuberculosis and archaetidylinositol phosphate synthase of Methanothermobacter thermautotrophicus is cloned in Escherichia coli and introduced into Streptomyces avermitilis cells. The recombinant cells show afterwards both, phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase activities, 76 pmol/h/mg and 20 pmol/h/mg, respectively, but no phosphatidylinositol synthase activity is detected, overview
Streptomyces avermitilis
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.8.11
Mn2+
required
Homo sapiens
2.7.8.11
Mn2+
required
Saccharomyces cerevisiae
2.7.8.B13
Mg2+
required
Corynebacterium glutamicum
2.7.8.B13
Mg2+
required
Cutibacterium acnes
2.7.8.B13
Mg2+
required
Rhodococcus hoagii
2.7.8.B13
Mg2+
required
Streptomyces avermitilis
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.8.11
CDP-diacylglycerol + myo-inositol
Homo sapiens
-
CMP + 1-phosphatidyl-1D-myo-inositol
-
-
?
2.7.8.11
CDP-diacylglycerol + myo-inositol
Saccharomyces cerevisiae
-
CMP + 1-phosphatidyl-1D-myo-inositol
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
Corynebacterium glutamicum
specificity of PIP synthase for lipid substrates
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
Rhodococcus hoagii
specificity of PIP synthase for lipid substrates
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
Mycobacterium tuberculosis variant bovis
specificity of PIP synthase for lipid substrates
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
Cutibacterium acnes
specificity of PIP synthase for lipid substrates
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
Streptomyces avermitilis
specificity of PIP synthase for lipid substrates
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
?
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.7.8.39
1783
-
pH 6.0, 80°C
Saccharolobus solfataricus
2.7.8.39
1867
-
pH 6.0, 80°C
Aeropyrum pernix
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.8.11
CDP-diacylglycerol + myo-inositol
-
726887
Homo sapiens
CMP + 1-phosphatidyl-1D-myo-inositol
-
-
-
?
2.7.8.11
CDP-diacylglycerol + myo-inositol
-
726887
Saccharomyces cerevisiae
CMP + 1-phosphatidyl-1D-myo-inositol
-
-
-
?
2.7.8.11
CDP-diacylglycerol + myo-inositol
specificity of PI synthase for the substrates, no activity with 1L-myo-inositol 1-phosphate
726887
Homo sapiens
CMP + 1-phosphatidyl-1D-myo-inositol
-
-
-
?
2.7.8.11
CDP-diacylglycerol + myo-inositol
specificity of PI synthase for the substrates, no activity with 1L-myo-inositol 1-phosphate
726887
Saccharomyces cerevisiae
CMP + 1-phosphatidyl-1D-myo-inositol
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
-
726887
Corynebacterium glutamicum
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
-
726887
Rhodococcus hoagii
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
-
726887
Mycobacterium tuberculosis variant bovis
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
-
726887
Cutibacterium acnes
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
-
726887
Streptomyces avermitilis
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
specificity of PIP synthase for lipid substrates
726887
Corynebacterium glutamicum
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
specificity of PIP synthase for lipid substrates
726887
Rhodococcus hoagii
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
specificity of PIP synthase for lipid substrates
726887
Mycobacterium tuberculosis variant bovis
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
specificity of PIP synthase for lipid substrates
726887
Cutibacterium acnes
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.B13
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate
specificity of PIP synthase for lipid substrates
726887
Streptomyces avermitilis
CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.39
CDP-2,3-bis-(O-phytanyl)-sn-glycerol + 1L-myo-inositol 1-phosphate
-
726887
Aeropyrum pernix
CMP + 1-archaetidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.39
CDP-2,3-bis-(O-phytanyl)-sn-glycerol + 1L-myo-inositol 1-phosphate
-
726887
Saccharolobus solfataricus
CMP + 1-archaetidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.39
CDP-2,3-bis-(O-phytanyl)-sn-glycerol + 1L-myo-inositol 1-phosphate
-
726887
Aeropyrum pernix DSM 11879
CMP + 1-archaetidyl-1D-myo-inositol 3-phosphate
-
-
-
?
2.7.8.39
CDP-2,3-bis-(O-phytanyl)-sn-glycerol + 1L-myo-inositol 1-phosphate
-
726887
Saccharolobus solfataricus P2
CMP + 1-archaetidyl-1D-myo-inositol 3-phosphate
-
-
-
?
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.7.8.11
30
-
assay at
Saccharomyces cerevisiae
2.7.8.11
37
-
assay at
Homo sapiens
2.7.8.B13
37
-
assay at
Corynebacterium glutamicum
2.7.8.B13
37
-
assay at
Cutibacterium acnes
2.7.8.B13
37
-
assay at
Rhodococcus hoagii
2.7.8.B13
37
-
assay at
Streptomyces avermitilis
2.7.8.39
80
-
assay at
Aeropyrum pernix
2.7.8.39
80
-
assay at
Saccharolobus solfataricus
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.7.8.11
8
-
assay at
Homo sapiens
2.7.8.11
8
-
assay at
Saccharomyces cerevisiae
2.7.8.B13
8
-
assay at
Corynebacterium glutamicum
2.7.8.B13
8
-
assay at
Cutibacterium acnes
2.7.8.B13
8
-
assay at
Rhodococcus hoagii
2.7.8.B13
8
-
assay at
Streptomyces avermitilis
2.7.8.39
6
-
assay at
Aeropyrum pernix
2.7.8.39
6
-
assay at
Saccharolobus solfataricus
General Information
EC Number
General Information
Commentary
Organism
2.7.8.11
metabolism
in eukarya, phosphatidylinositol (PI) is only biosynthesized from CDP-diacylglycerol (CDP-DAG) and inositol
Homo sapiens
2.7.8.11
metabolism
in eukarya, phosphatidylinositol (PI) is only biosynthesized from CDP-diacylglycerol (CDP-DAG) and inositol
Saccharomyces cerevisiae
2.7.8.B13
metabolism
in bacteria, an inositol phospholipid biosynthetic pathway uses precursors inositol 1-phosphate and CDP-DAG to form phosphatidylinositol phosphate (PIP) as intermediate by action of the key enzyme PIP synthase. The intermediate is dephosphorylated to synthesize phosphatidylinositol. The biosynthetic pathway is universal in bacteria which contain inositol phospholipid
Corynebacterium glutamicum
2.7.8.B13
metabolism
in bacteria, an inositol phospholipid biosynthetic pathway uses precursors inositol 1-phosphate and CDP-DAG to form phosphatidylinositol phosphate (PIP) as intermediate by action of the key enzyme PIP synthase. The intermediate is dephosphorylated to synthesize phosphatidylinositol. The biosynthetic pathway is universal in bacteria which contain inositol phospholipid
Cutibacterium acnes
2.7.8.B13
metabolism
in bacteria, an inositol phospholipid biosynthetic pathway uses precursors inositol 1-phosphate and CDP-DAG to form phosphatidylinositol phosphate (PIP) as intermediate by action of the key enzyme PIP synthase. The intermediate is dephosphorylated to synthesize phosphatidylinositol. The biosynthetic pathway is universal in bacteria which contain inositol phospholipid
Mycobacterium tuberculosis variant bovis
2.7.8.B13
metabolism
in bacteria, an inositol phospholipid biosynthetic pathway uses precursors inositol 1-phosphate and CDP-DAG to form phosphatidylinositol phosphate (PIP) as intermediate by action of the key enzyme PIP synthase. The intermediate is dephosphorylated to synthesize phosphatidylinositol. The biosynthetic pathway is universal in bacteria which contain inositol phospholipid
Rhodococcus hoagii
2.7.8.B13
metabolism
in bacteria, an inositol phospholipid biosynthetic pathway uses precursors inositol 1-phosphate and CDP-DAG to form phosphatidylinositol phosphate (PIP) as intermediate by action of the key enzyme PIP synthase. The intermediate is dephosphorylated to synthesize phosphatidylinositol. The biosynthetic pathway is universal in bacteria which contain inositol phospholipid
Streptomyces avermitilis
General Information (protein specific)
EC Number
General Information
Commentary
Organism
2.7.8.11
metabolism
in eukarya, phosphatidylinositol (PI) is only biosynthesized from CDP-diacylglycerol (CDP-DAG) and inositol
Homo sapiens
2.7.8.11
metabolism
in eukarya, phosphatidylinositol (PI) is only biosynthesized from CDP-diacylglycerol (CDP-DAG) and inositol
Saccharomyces cerevisiae
2.7.8.B13
metabolism
in bacteria, an inositol phospholipid biosynthetic pathway uses precursors inositol 1-phosphate and CDP-DAG to form phosphatidylinositol phosphate (PIP) as intermediate by action of the key enzyme PIP synthase. The intermediate is dephosphorylated to synthesize phosphatidylinositol. The biosynthetic pathway is universal in bacteria which contain inositol phospholipid
Corynebacterium glutamicum
2.7.8.B13
metabolism
in bacteria, an inositol phospholipid biosynthetic pathway uses precursors inositol 1-phosphate and CDP-DAG to form phosphatidylinositol phosphate (PIP) as intermediate by action of the key enzyme PIP synthase. The intermediate is dephosphorylated to synthesize phosphatidylinositol. The biosynthetic pathway is universal in bacteria which contain inositol phospholipid
Cutibacterium acnes
2.7.8.B13
metabolism
in bacteria, an inositol phospholipid biosynthetic pathway uses precursors inositol 1-phosphate and CDP-DAG to form phosphatidylinositol phosphate (PIP) as intermediate by action of the key enzyme PIP synthase. The intermediate is dephosphorylated to synthesize phosphatidylinositol. The biosynthetic pathway is universal in bacteria which contain inositol phospholipid
Mycobacterium tuberculosis variant bovis
2.7.8.B13
metabolism
in bacteria, an inositol phospholipid biosynthetic pathway uses precursors inositol 1-phosphate and CDP-DAG to form phosphatidylinositol phosphate (PIP) as intermediate by action of the key enzyme PIP synthase. The intermediate is dephosphorylated to synthesize phosphatidylinositol. The biosynthetic pathway is universal in bacteria which contain inositol phospholipid
Rhodococcus hoagii
2.7.8.B13
metabolism
in bacteria, an inositol phospholipid biosynthetic pathway uses precursors inositol 1-phosphate and CDP-DAG to form phosphatidylinositol phosphate (PIP) as intermediate by action of the key enzyme PIP synthase. The intermediate is dephosphorylated to synthesize phosphatidylinositol. The biosynthetic pathway is universal in bacteria which contain inositol phospholipid
Streptomyces avermitilis