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Literature summary extracted from

  • Smith, M.E.; Saraceno, G.E.; Capani, F.; Castilla, R.
    Long-chain acyl-CoA synthetase 4 is regulated by phosphorylation (2013), Biochem. Biophys. Res. Commun., 430, 272-277.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.3 mitochondrial membrane
-
 Mus musculus 31966
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.2.1.3 74000
-
 2 * 74000, SDS-PAGE Mus musculus
6.2.1.3 150000
-
 gel filtration Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.3 ATP + arachidonate + CoA Mus musculus preferred substrate AMP + diphosphate + arachidonoyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.3 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
6.2.1.3 phosphoprotein the phosphorylation of the enzyme by protein kinase A and protein kinase C is hormone-dependent. Phosphorylation occurs after active dimer formation Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.3 adrenocortical tumor cell
-
 Mus musculus
-
6.2.1.3 Y-1 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.3 ATP + arachidonate + CoA preferred substrate Mus musculus AMP + diphosphate + arachidonoyl-CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
6.2.1.3 homodimer 2 * 74000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
6.2.1.3 ACSL4
-
 Mus musculus
6.2.1.3 long-chain acyl-CoA synthetase 4
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.3 ATP
-
 Mus musculus

General Information

EC Number General Information Comment Organism
6.2.1.3 metabolism long chain acyl CoA synthetase 4 is a key enzyme in steroidogenesis. It participates in steroid synthesis through of arachidonic acid release and steroidogenic acute regulatory protein induction Mus musculus