Literature summary extracted from
Dimou, M.; Zografou, C.; Venieraki, A.; Katinakis, P.
Functional interaction of Azotobacter vinelandii cytoplasmic cyclophilin with the biotin carboxylase subunit of acetyl-CoA carboxylase (2012), Biochem. Biophys. Res. Commun., 424, 736-739.
Activating Compound
EC Number |
Activating Compound |
Comment |
Organism |
Structure |
---|
6.3.4.14 |
cyclophilin |
cyclophilin stimulates the ATP hydrolysis activity of the enzyme (8fold stimulation of activity at 10fold molar excess over the enzyme) |
Azotobacter vinelandii |
|
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
6.3.4.14 |
expressed in Escherichia coli |
Azotobacter vinelandii |
Localization
EC Number |
Localization |
Comment |
Organism |
GeneOntology No. |
Textmining |
---|
Natural Substrates/ Products (Substrates)
EC Number |
Natural Substrates |
Organism |
Comment (Nat. Sub.) |
Natural Products |
Comment (Nat. Pro.) |
Rev. |
Reac. |
---|
6.3.4.14 |
ATP + biotin-carboxyl-carrier protein + HCO3- |
Azotobacter vinelandii |
- |
ADP + phosphate + carboxybiotin-carboxyl-carrier protein |
- |
? |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
6.3.4.14 |
Azotobacter vinelandii |
C1DLJ7 |
- |
- |
Purification (Commentary)
EC Number |
Purification (Comment) |
Organism |
---|
6.3.4.14 |
Ni-NTA column chromatography |
Azotobacter vinelandii |
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
6.3.4.14 |
ATP + biotin-carboxyl-carrier protein + HCO3- |
- |
Azotobacter vinelandii |
ADP + phosphate + carboxybiotin-carboxyl-carrier protein |
- |
? |
|
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
6.3.4.14 |
AccC |
biotin carboxylase subunit of acetyl-CoA carboxylase |
Azotobacter vinelandii |
Cofactor
EC Number |
Cofactor |
Comment |
Organism |
Structure |
---|
6.3.4.14 |
ATP |
- |
Azotobacter vinelandii |
|
General Information
EC Number |
General Information |
Comment |
Organism |
---|
6.3.4.14 |
metabolism |
the enzyme shows inhibitory effect of on the peptidyl-prolyl cis/trans isomerase activity of cyclophilin (49% inhibition at 40fold molar excess over ppiB). Conversely, cyclophilin stimulates the ATP hydrolysis activity of the enzyme |
Azotobacter vinelandii |