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Literature summary extracted from

  • Bao, B.; Wijeratne, S.S.; Rodriguez-Melendez, R.; Zempleni, J.
    Human holocarboxylase synthetase with a start site at methionine-58 is the predominant nuclear variant of this protein and has catalytic activity (2011), Biochem. Biophys. Res. Commun., 412, 115-120.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.4.10 expressed in HEK-293 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.3.4.10 cytoplasm localizes predominantly in the cytoplasm Homo sapiens 5737
-
6.3.4.10 nucleus
-
 Homo sapiens 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.4.10 115000
-
 N-terminal glutathione S transferase-tagged enzyme, x * 115000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.4.10 ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] Homo sapiens
-
 AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.10 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.10 ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
 Homo sapiens AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.4.10 ? N-terminal glutathione S transferase-tagged enzyme, x * 115000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
6.3.4.10 HLCS
-
 Homo sapiens
6.3.4.10 Holocarboxylase synthetase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.4.10 ATP
-
 Homo sapiens