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Literature summary extracted from

  • Moreschi, I.; Bruzzone, S.; Melone, L.; De Flora, A.; Zocchi, E.
    NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases (2006), Biochem. Biophys. Res. Commun., 345, 573-580.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.4.99.20 Aplysia californica P29241
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-
2.4.99.20 Axinella polypoides
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-
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2.4.99.20 Homo sapiens P28907
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.99.20 2'-phospho-cyclic ADP-ribose + nicotinate
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 Aplysia californica nicotinate-adenine dinucleotide phosphate enzyme shows a higher NAADP+-producing activity at pH 5.0 than at pH 7.4. At pH 5.0 the formation of NAADP+ is even more predominant than cADPRP hydrolysis, reaction of EC 3.2.2.6 ?
2.4.99.20 2'-phospho-cyclic ADP-ribose + nicotinate
-
 Axinella polypoides nicotinate-adenine dinucleotide phosphate enzyme shows a higher NAADP+-producing activity at pH 5.0 than at pH 7.4. At pH 5.0 the formation of NAADP+ is even more predominant than cADPRP hydrolysis, reaction of EC 3.2.2.6 ?
2.4.99.20 2'-phospho-cyclic ADP-ribose + nicotinate
-
 Homo sapiens nicotinate-adenine dinucleotide phosphate the synthesis of nicotinate-adenine dinucleotide phosphate from 2'-phospho-cyclic ADP-ribose is as efficient as the hydrolysis of the cyclic nucleotide at pH 5.0, reaction of EC 3.2.2.6, while at pH 7.4 the hydrolase activity is predominant ?
2.4.99.20 additional information enzyme is more efficient in catalyzing the removal of the nicotinamide moiety than in the base-exchange reaction Homo sapiens ?
-
 ?
2.4.99.20 additional information enzyme is more efficient in catalyzing the removal of the nicotinamide moiety than in the base-exchange reaction Aplysia californica ?
-
 ?
2.4.99.20 additional information enzyme is more efficient in catalyzing the removal of the nicotinamide moiety than in the base-exchange reaction Axinella polypoides ?
-
 ?
2.4.99.20 NADP+
-
 Homo sapiens 2'-phospho-cyclic ADP-ribose + nicotinamide
-
 ?
2.4.99.20 NADP+
-
 Aplysia californica 2'-phospho-cyclic ADP-ribose + nicotinamide
-
 ?
2.4.99.20 NADP+
-
 Axinella polypoides 2'-phospho-cyclic ADP-ribose + nicotinamide
-
 ?