EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.14.154 | expressed in Escherichia coli DH5alpha cells | Candida albicans |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.14.14.154 | D116E | the azole Kd value of the mutant enzyme is little altered compared to the wild type enzyme | Candida albicans |
1.14.14.154 | F105L | the azole Kd value of the mutant enzyme is little altered compared to the wild type enzyme | Candida albicans |
1.14.14.154 | R467K | the azole Kd value of the mutant enzyme is little altered compared to the wild type enzyme | Candida albicans |
1.14.14.154 | Y132H | the azole Kd value of the mutant enzyme is clearly altered compared to the wild type enzyme | Candida albicans |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.154 | econazole | - |
Candida albicans | |
1.14.14.154 | fluconazole | - |
Candida albicans | |
1.14.14.154 | itraconazole | - |
Candida albicans | |
1.14.14.154 | ketoconazole | - |
Candida albicans |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.14.14.154 | 61500 | - |
x * 61500, SDS-PAGE | Candida albicans |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.154 | Candida albicans | P10613 | - |
- |
1.14.14.154 | Candida albicans ATCC MYA-2876 | P10613 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.14.14.154 | Ni-NTA column chromatography, and gel filtration | Candida albicans |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.154 | lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Candida albicans | 4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.154 | lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Candida albicans ATCC MYA-2876 | 4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.14.14.154 | ? | x * 61500, SDS-PAGE | Candida albicans |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.14.154 | CYP51F1 | - |
Candida albicans |
1.14.14.154 | lanosterol 14alpha-demethylase | - |
Candida albicans |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.154 | heme | - |
Candida albicans |