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Literature summary extracted from

  • Fernandez-Aguado, M.; Teijeira, F.; Martin, J.F.; Ullan, R.V.
    A vacuolar membrane protein affects drastically the biosynthesis of the ACV tripeptide and the beta-lactam pathway of Penicillium chrysogenum (2013), Appl. Microbiol. Biotechnol., 97, 795-808.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.2.26 gene pcbAB Penicillium chrysogenum

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.26 additional information PenV i.e. Pc22g22150 protein, located in the vacuolar membrane, affects drastically the biosynthesis of the ACV tripeptide and the beta-lactam pathway of Penicillium chrysogenum, overview Penicillium chrysogenum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.2.26 Mg2+ required Penicillium chrysogenum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.26 3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O Penicillium chrysogenum
-
 3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
-
 ?
6.3.2.26 3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O Penicillium chrysogenum Wisconsin 54-1255
-
 3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.26 Penicillium chrysogenum B6HLU1 a low penicillin production strain, gene pcbAB
-
6.3.2.26 Penicillium chrysogenum Wisconsin 54-1255 B6HLU1 a low penicillin production strain, gene pcbAB
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.26 3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O
-
 Penicillium chrysogenum 3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
-
 ?
6.3.2.26 3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O
-
 Penicillium chrysogenum Wisconsin 54-1255 3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.26 ACV synthetase
-
 Penicillium chrysogenum
6.3.2.26 delta-(L-alpha-aminoadipyl-L-cysteinyl-D-valine synthetase)
-
 Penicillium chrysogenum

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.2.26 ATP
-
 Penicillium chrysogenum

General Information

EC Number General Information Comment Organism
6.3.2.26 malfunction RNAi-mediated silencing of penV gene, encoding protein Pc22g22150, UniProt-ID B6HTR9, provokes a drastic reduction of the production of the delta-(L-alpha-aminoadipyl-L-cysteinyl-D-valine) and isopenicillin N intermediates and the final product of the pathway Penicillium chrysogenum
6.3.2.26 physiological function the enzyme catalyzes the non-ribosomal activation and condensation of the three constituent amino acids to form the tripeptide N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine, i.e. ACV Penicillium chrysogenum