EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
5.4.99.17 | F409C | site-directed mutagenesis, the mutant does not perform interconversion of citronellal and isopulegol | Bacillus anthracis |
5.4.99.17 | F436C | site-directed mutagenesis, the mutant does not perform interconversion of citronellal and isopulegol | Burkholderia ambifaria |
5.4.99.17 | F438C | site-directed mutagenesis, the mutant does not perform interconversion of citronellal and isopulegol | Teredinibacter turnerae |
5.4.99.17 | F438C | site-directed mutagenesis, the mutant does not perform interconversion of citronellal and isopulegol | Streptomyces coelicolor |
5.4.99.17 | F438C | site-directed mutagenesis, the mutant performs interconversion of citronellal and isopulegol | Zymomonas mobilis |
5.4.99.17 | F445C | site-directed mutagenesis, the mutant does not perform interconversion of citronellal and isopulegol | Rhodopseudomonas palustris |
5.4.99.17 | F447C | site-directed mutagenesis, the mutant performs interconversion of citronellal and isopulegol | Bradyrhizobium japonicum |
5.4.99.17 | F450C | site-directed mutagenesis, the mutant does not perform interconversion of citronellal and isopulegol | Burkholderia ambifaria |
5.4.99.17 | F457C | site-directed mutagenesis, the mutant does not perform interconversion of citronellal and isopulegol | Syntrophobacter fumaroxidans |
5.4.99.17 | F481C | site-directed mutagenesis, the mutant performs interconversion of citronellal and isopulegol | Acetobacter pasteurianus |
5.4.99.17 | F486C | site-directed mutagenesis, the mutant shows increased activity in interconversion of citronellal and isopulegol compared to the wild-type enzyme | Zymomonas mobilis |
5.4.99.17 | W555A | site-directed mutagenesis, the mutant shows no squalene hopene cyclase activity, and low citronellal cyclase activity | Zymomonas mobilis |
5.4.99.17 | W555C | site-directed mutagenesis, the mutant shows no squalene hopene cyclase activity, and low citronellal cyclase activity | Zymomonas mobilis |
5.4.99.17 | W555D | site-directed mutagenesis, the mutant shows no squalene hopene cyclase activity, and moderate citronellal cyclase activity | Zymomonas mobilis |
5.4.99.17 | W555E | site-directed mutagenesis, the mutant shows highly reduced squalene hopene cyclase activity, and low citronellal cyclase activity | Zymomonas mobilis |
5.4.99.17 | W555F | site-directed mutagenesis, the mutant shows no squalene hopene cyclase activity, and higher citronellal cyclase activity | Zymomonas mobilis |
5.4.99.17 | W555F | W555 is essential for hopene formation but W555Y and W555F have enhanced citronellal cyclase activity. All muteins of position W555 show abolished or strongly reduced hopene-forming activity compared to wild-type protein. W555Y is the only mutein with low but significant residual SHC activity | Zymomonas mobilis |
5.4.99.17 | W555G | site-directed mutagenesis, the mutant shows no squalene hopene cyclase activity, and low citronellal cyclase activity | Zymomonas mobilis |
5.4.99.17 | W555H | site-directed mutagenesis, the mutant shows no squalene hopene cyclase activity, and moderate citronellal cyclase activity | Zymomonas mobilis |
5.4.99.17 | W555I | site-directed mutagenesis, the mutant shows no squalene hopene cyclase activity, and low citronellal cyclase activity | Zymomonas mobilis |
5.4.99.17 | W555K | site-directed mutagenesis, the mutant shows no squalene hopene cyclase activity, and low citronellal cyclase activity | Zymomonas mobilis |
5.4.99.17 | W555L | site-directed mutagenesis, the mutant shows no squalene hopene cyclase activity, and low citronellal cyclase activity | Zymomonas mobilis |
5.4.99.17 | W555M | site-directed mutagenesis, the mutant shows highly reduced squalene hopene cyclase activity, and low citronellal cyclase activity | Zymomonas mobilis |
5.4.99.17 | W555N | site-directed mutagenesis, the mutant shows highly reduced squalene hopene cyclase activity, and moderate citronellal cyclase activity | Zymomonas mobilis |
5.4.99.17 | W555P | site-directed mutagenesis, the mutant shows no squalene hopene cyclase activity, and low citronellal cyclase activity | Zymomonas mobilis |
5.4.99.17 | W555Q | site-directed mutagenesis, the mutant shows highly reduced squalene hopene cyclase activity, and low citronellal cyclase activity | Zymomonas mobilis |
5.4.99.17 | W555R | site-directed mutagenesis, the mutant shows no squalene hopene cyclase activity, and low citronellal cyclase activity | Zymomonas mobilis |
5.4.99.17 | W555S | site-directed mutagenesis, the mutant shows no squalene hopene cyclase activity, and low citronellal cyclase activity | Zymomonas mobilis |
5.4.99.17 | W555T | site-directed mutagenesis, the mutant shows no squalene hopene cyclase activity, and higher citronellal cyclase activity | Zymomonas mobilis |
5.4.99.17 | W555V | site-directed mutagenesis, the mutant shows no squalene hopene cyclase activity, and low citronellal cyclase activity | Zymomonas mobilis |
5.4.99.17 | W555Y | site-directed mutagenesis, the mutant shows highly reduced squalene hopene cyclase activity,and higher citronellal cyclase activity | Zymomonas mobilis |
5.4.99.17 | W555Y | W555 is essential for hopene formation but W555Y and W555F have enhanced citronellal cyclase activity. All muteins of position W555 show abolished or strongly reduced hopene-forming activity compared to wild-type protein. W555Y is the only mutein with low but significant residual SHC activity | Zymomonas mobilis |
5.4.99.17 | Y420C | site-directed mutagenesis, the mutant performs interconversion of citronellal and isopulegol | Alicyclobacillus acidocaldarius |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.4.99.17 | citronellal | Zymomonas mobilis | - |
isopulegol | i.e. 2-isopropenyl-5-methyl-cyclohexanol | ? | |
5.4.99.17 | citronellal | Zymomonas mobilis CP4 | - |
isopulegol | i.e. 2-isopropenyl-5-methyl-cyclohexanol | ? | |
5.4.99.17 | additional information | Bradyrhizobium japonicum | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | ? | - |
? | |
5.4.99.17 | additional information | Rhodopseudomonas palustris | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | ? | - |
? | |
5.4.99.17 | additional information | Alicyclobacillus acidocaldarius | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | ? | - |
? | |
5.4.99.17 | additional information | Zymomonas mobilis | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | ? | - |
? | |
5.4.99.17 | additional information | Acetobacter pasteurianus | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | ? | - |
? | |
5.4.99.17 | additional information | Syntrophobacter fumaroxidans | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | ? | - |
? | |
5.4.99.17 | additional information | Teredinibacter turnerae | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | ? | - |
? | |
5.4.99.17 | additional information | Bacillus anthracis | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | ? | - |
? | |
5.4.99.17 | additional information | Streptomyces coelicolor | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | ? | - |
? | |
5.4.99.17 | additional information | Burkholderia ambifaria | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | ? | - |
? | |
5.4.99.17 | additional information | Burkholderia ambifaria ATCC BAA-244 / AMMD | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | ? | - |
? | |
5.4.99.17 | additional information | Zymomonas mobilis ATCC 31821 | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | ? | - |
? | |
5.4.99.17 | additional information | Alicyclobacillus acidocaldarius DSM 446 | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | ? | - |
? | |
5.4.99.17 | squalene | Bradyrhizobium japonicum | - |
hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | Rhodopseudomonas palustris | - |
hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | Alicyclobacillus acidocaldarius | - |
hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | Zymomonas mobilis | - |
hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | Acetobacter pasteurianus | - |
hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | Syntrophobacter fumaroxidans | - |
hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | Teredinibacter turnerae | - |
hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | Bacillus anthracis | - |
hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | Streptomyces coelicolor | - |
hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | Burkholderia ambifaria | - |
hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | Burkholderia ambifaria ATCC BAA-244 / AMMD | - |
hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | Zymomonas mobilis ATCC 31821 | - |
hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | Zymomonas mobilis CP4 | - |
hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | Alicyclobacillus acidocaldarius DSM 446 | - |
hop-22(29)-ene | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.4.99.17 | Acetobacter pasteurianus | YP3187836 | - |
- |
5.4.99.17 | Alicyclobacillus acidocaldarius | P33247 | - |
- |
5.4.99.17 | Alicyclobacillus acidocaldarius DSM 446 | P33247 | - |
- |
5.4.99.17 | Bacillus anthracis | Q81YD8 | - |
- |
5.4.99.17 | Bradyrhizobium japonicum | - |
- |
- |
5.4.99.17 | Burkholderia ambifaria | Q0B2H5 | - |
- |
5.4.99.17 | Burkholderia ambifaria | Q0B5S3 | - |
- |
5.4.99.17 | Burkholderia ambifaria ATCC BAA-244 / AMMD | Q0B2H5 | - |
- |
5.4.99.17 | Burkholderia ambifaria ATCC BAA-244 / AMMD | Q0B5S3 | - |
- |
5.4.99.17 | Rhodopseudomonas palustris | - |
- |
- |
5.4.99.17 | Streptomyces coelicolor | Q9X7V9 | - |
- |
5.4.99.17 | Syntrophobacter fumaroxidans | A0LJS0 | - |
- |
5.4.99.17 | Teredinibacter turnerae | - |
- |
- |
5.4.99.17 | Zymomonas mobilis | P33990 | - |
- |
5.4.99.17 | Zymomonas mobilis | Q5NM88 | - |
- |
5.4.99.17 | Zymomonas mobilis ATCC 31821 | P33990 | - |
- |
5.4.99.17 | Zymomonas mobilis CP4 | Q5NM88 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.4.99.17 | citronellal | - |
Zymomonas mobilis | isopulegol | i.e. 2-isopropenyl-5-methyl-cyclohexanol | ? | |
5.4.99.17 | citronellal | activity of mutant F438C, not of the wild-type enzyme | Zymomonas mobilis | isopulegol | i.e. 2-isopropenyl-5-methyl-cyclohexanol | ? | |
5.4.99.17 | citronellal | activity of mutant F447C, not of the wild-type enzyme | Bradyrhizobium japonicum | isopulegol | i.e. 2-isopropenyl-5-methyl-cyclohexanol | ? | |
5.4.99.17 | citronellal | activity of mutant F449C, not of the wild-type enzyme | Streptomyces coelicolor | isopulegol | i.e. 2-isopropenyl-5-methyl-cyclohexanol | ? | |
5.4.99.17 | citronellal | activity of mutant F481C, not of the wild-type enzyme | Acetobacter pasteurianus | isopulegol | i.e. 2-isopropenyl-5-methyl-cyclohexanol | ? | |
5.4.99.17 | citronellal | activity of mutant Y420C, not of the wild-type enzyme | Alicyclobacillus acidocaldarius | isopulegol | i.e. 2-isopropenyl-5-methyl-cyclohexanol | ? | |
5.4.99.17 | citronellal | wild-type enzyme, and increased activity in mutant F486C | Zymomonas mobilis | isopulegol | i.e. 2-isopropenyl-5-methyl-cyclohexanol | ? | |
5.4.99.17 | citronellal | activity of mutant F438C, not of the wild-type enzyme | Zymomonas mobilis ATCC 31821 | isopulegol | i.e. 2-isopropenyl-5-methyl-cyclohexanol | ? | |
5.4.99.17 | citronellal | - |
Zymomonas mobilis CP4 | isopulegol | i.e. 2-isopropenyl-5-methyl-cyclohexanol | ? | |
5.4.99.17 | citronellal | wild-type enzyme, and increased activity in mutant F486C | Zymomonas mobilis CP4 | isopulegol | i.e. 2-isopropenyl-5-methyl-cyclohexanol | ? | |
5.4.99.17 | citronellal | activity of mutant Y420C, not of the wild-type enzyme | Alicyclobacillus acidocaldarius DSM 446 | isopulegol | i.e. 2-isopropenyl-5-methyl-cyclohexanol | ? | |
5.4.99.17 | additional information | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | Bradyrhizobium japonicum | ? | - |
? | |
5.4.99.17 | additional information | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | Rhodopseudomonas palustris | ? | - |
? | |
5.4.99.17 | additional information | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | Alicyclobacillus acidocaldarius | ? | - |
? | |
5.4.99.17 | additional information | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | Zymomonas mobilis | ? | - |
? | |
5.4.99.17 | additional information | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | Acetobacter pasteurianus | ? | - |
? | |
5.4.99.17 | additional information | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | Syntrophobacter fumaroxidans | ? | - |
? | |
5.4.99.17 | additional information | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | Teredinibacter turnerae | ? | - |
? | |
5.4.99.17 | additional information | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | Bacillus anthracis | ? | - |
? | |
5.4.99.17 | additional information | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | Streptomyces coelicolor | ? | - |
? | |
5.4.99.17 | additional information | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | Burkholderia ambifaria | ? | - |
? | |
5.4.99.17 | additional information | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | Burkholderia ambifaria ATCC BAA-244 / AMMD | ? | - |
? | |
5.4.99.17 | additional information | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | Zymomonas mobilis ATCC 31821 | ? | - |
? | |
5.4.99.17 | additional information | no activity with citronellal or isopulegol (2-isopropenyl-5-methyl-cyclohexanol) | Alicyclobacillus acidocaldarius DSM 446 | ? | - |
? | |
5.4.99.17 | squalene | - |
Bradyrhizobium japonicum | hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | - |
Rhodopseudomonas palustris | hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | - |
Alicyclobacillus acidocaldarius | hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | - |
Zymomonas mobilis | hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | - |
Acetobacter pasteurianus | hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | - |
Syntrophobacter fumaroxidans | hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | - |
Teredinibacter turnerae | hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | - |
Bacillus anthracis | hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | - |
Streptomyces coelicolor | hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | - |
Burkholderia ambifaria | hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | - |
Burkholderia ambifaria ATCC BAA-244 / AMMD | hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | - |
Zymomonas mobilis ATCC 31821 | hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | - |
Zymomonas mobilis CP4 | hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene | - |
Alicyclobacillus acidocaldarius DSM 446 | hop-22(29)-ene | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.4.99.17 | SHC | - |
Bradyrhizobium japonicum |
5.4.99.17 | SHC | - |
Rhodopseudomonas palustris |
5.4.99.17 | SHC | - |
Alicyclobacillus acidocaldarius |
5.4.99.17 | SHC | - |
Zymomonas mobilis |
5.4.99.17 | SHC | - |
Acetobacter pasteurianus |
5.4.99.17 | SHC | - |
Syntrophobacter fumaroxidans |
5.4.99.17 | SHC | - |
Teredinibacter turnerae |
5.4.99.17 | SHC | - |
Bacillus anthracis |
5.4.99.17 | SHC | - |
Streptomyces coelicolor |
5.4.99.17 | SHC | - |
Burkholderia ambifaria |
5.4.99.17 | SHC1 | - |
Burkholderia ambifaria |
5.4.99.17 | SHC2 | - |
Burkholderia ambifaria |