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Literature summary extracted from

  • Freedman, Z.; Zhu, C.; Barkay, T.
    Mercury resistance and mercuric reductase activities and expression among chemotrophic thermophilic Aquificae (2012), Appl. Environ. Microbiol., 78, 6568-6575.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.16.1.1 gene merA, DNA and amino acid sequence determination and analysis, phylogenetic analysis Hydrogenobaculum sp. Y04AAS1
1.16.1.1 gene merA, DNA and amino acid sequence determination and analysis, phylogenetic analysis Hydrogenivirga sp. 128-5-R1-1

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.16.1.1 Hg + NAD+ + H+ Hydrogenobaculum sp. Y04AAS1
-
 Hg2+ + NADH
-
 r
1.16.1.1 Hg + NAD+ + H+ Hydrogenivirga sp. 128-5-R1-1
-
 Hg2+ + NADH
-
 r
1.16.1.1 Hg + NADP+ + H+ Hydrogenobaculum sp. Y04AAS1
-
 Hg2+ + NADPH
-
 r
1.16.1.1 Hg + NADP+ + H+ Hydrogenivirga sp. 128-5-R1-1
-
 Hg2+ + NADPH
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.16.1.1 Hydrogenivirga sp. 128-5-R1-1 A8UT36
-
-
1.16.1.1 Hydrogenobaculum sp. Y04AAS1 B4U9T7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.16.1.1 additional information strain AAS1 is resistant to concentration over 0.01 mM Hg2+, transforms Hg(II) to Hg(0) during cellular growth, and possesses Hg-dependent NAD(P)H oxidation activities in crude cell extracts that are optimal at temperatures corresponding with the strains' optimal growth temperature of 55°C Hydrogenobaculum sp. Y04AAS1
-
1.16.1.1 additional information strain R1-1 is resistant to concentration of over 0.01 mM Hg2+, transforms Hg(II) to Hg(0) during cellular growth, and possesses Hg-dependent NAD(P)H oxidation activities in crude cell extracts that are optimal at temperatures corresponding with the strains' optimal growth temperature of 70°C Hydrogenivirga sp. 128-5-R1-1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.16.1.1 Hg + NAD+ + H+
-
 Hydrogenobaculum sp. Y04AAS1 Hg2+ + NADH
-
 r
1.16.1.1 Hg + NAD+ + H+
-
 Hydrogenivirga sp. 128-5-R1-1 Hg2+ + NADH
-
 r
1.16.1.1 Hg + NADP+ + H+
-
 Hydrogenobaculum sp. Y04AAS1 Hg2+ + NADPH
-
 r
1.16.1.1 Hg + NADP+ + H+
-
 Hydrogenivirga sp. 128-5-R1-1 Hg2+ + NADPH
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.16.1.1 MerA
-
 Hydrogenivirga sp. 128-5-R1-1
1.16.1.1 mercuric reductase
-
 Hydrogenobaculum sp. Y04AAS1
1.16.1.1 mercuric reductase
-
 Hydrogenivirga sp. 128-5-R1-1

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.16.1.1 50
-
-
 Hydrogenobaculum sp. Y04AAS1
1.16.1.1 70
-
-
 Hydrogenivirga sp. 128-5-R1-1

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
1.16.1.1 30 70 activity range, very low activity below 40°C Hydrogenobaculum sp. Y04AAS1
1.16.1.1 60 87 activity range, very low activities below 40°C Hydrogenivirga sp. 128-5-R1-1

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.16.1.1 7.4
-
 assay at Hydrogenobaculum sp. Y04AAS1
1.16.1.1 7.4
-
 assay at Hydrogenivirga sp. 128-5-R1-1

Cofactor

EC Number Cofactor Comment Organism Structure
1.16.1.1 NAD+
-
 Hydrogenobaculum sp. Y04AAS1
1.16.1.1 NAD+
-
 Hydrogenivirga sp. 128-5-R1-1
1.16.1.1 NADH
-
 Hydrogenobaculum sp. Y04AAS1
1.16.1.1 NADH
-
 Hydrogenivirga sp. 128-5-R1-1
1.16.1.1 NADP+
-
 Hydrogenobaculum sp. Y04AAS1
1.16.1.1 NADP+
-
 Hydrogenivirga sp. 128-5-R1-1
1.16.1.1 NADPH
-
 Hydrogenobaculum sp. Y04AAS1
1.16.1.1 NADPH
-
 Hydrogenivirga sp. 128-5-R1-1

Expression

EC Number Organism Comment Expression
1.16.1.1 Hydrogenobaculum sp. Y04AAS1 the enzyme is induced by Hg up
1.16.1.1 Hydrogenivirga sp. 128-5-R1-1 the enzyme is induced by Hg up

General Information

EC Number General Information Comment Organism
1.16.1.1 additional information strain R1-1 is resistant to concentration of over 0.01 mM Hg2+, transforms Hg(II) to Hg(0) during cellular growth, and possesses Hg-dependent NAD(P)H oxidation activities in crude cell extracts that are optimal at temperatures corresponding with the strains' optimal growth temperature of 70°C Hydrogenivirga sp. 128-5-R1-1