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Literature summary extracted from
- D-Ala-d-Ser VanN-type transferable vancomycin resistance in Enterococcus faecium (2011), Antimicrob. Agents Chemother., 55, 4606-4612.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 6.3.2.35 | vanL, chromosomal localization, belongs to the vanN operon, genetic organization, DNA and amino acid sequence determination and analysis, sequence comparisons with VanN-type proteins, phylogenetic analysis | Enterococcus faecium |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 6.3.2.35 | Mg2+ | required | Enterococcus faecium |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 6.3.2.35 | D-alanine + D-serine + ATP | Enterococcus faecium | - |
D-alanyl-D-serine + ADP + phosphate | - |
? | |
| 6.3.2.35 | D-alanine + D-serine + ATP | Enterococcus faecium UCN71 | - |
D-alanyl-D-serine + ADP + phosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 6.3.2.35 | Enterococcus faecium | - |
isolated from a blood culture | - |
| 6.3.2.35 | Enterococcus faecium UCN71 | - |
isolated from a blood culture | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 6.3.2.35 | D-alanine + D-serine + ATP | - |
Enterococcus faecium | D-alanyl-D-serine + ADP + phosphate | - |
? | |
| 6.3.2.35 | D-alanine + D-serine + ATP | - |
Enterococcus faecium UCN71 | D-alanyl-D-serine + ADP + phosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 6.3.2.35 | D-alanine:D-serine ligase | - |
Enterococcus faecium |
| 6.3.2.35 | VanL | - |
Enterococcus faecium |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 6.3.2.35 | ATP | - |
Enterococcus faecium | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 6.3.2.35 | physiological function | the enzyme VanL belongs to the vancomycin resistance ligases | Enterococcus faecium |
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