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Literature summary extracted from

  • Lee, H.C.; Graeff, R.M.; Walseth, T.F.
    ADP-ribosyl cyclase and CD38. Multi-functional enzymes in Ca+2 signaling (1997), Adv. Exp. Med. Biol., 419, 411-419.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.99.20 enzyme is a dimer Aplysia californica

Organism

EC Number Organism UniProt Comment Textmining
2.4.99.20 Aplysia californica P29241
-
-
2.4.99.20 Homo sapiens P28907
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.99.20 2'-phospho-cyclic ADP-ribose + nicotinate
-
 Homo sapiens nicotinate-adenine dinucleotide phosphate
-
 ?
2.4.99.20 2'-phospho-cyclic ADP-ribose + nicotinate
-
 Aplysia californica nicotinate-adenine dinucleotide phosphate
-
 ?
2.4.99.20 additional information enzymes cyclizes NAD to cADPR. In the presence of nicotinic acid, it catalyzes a base exchange reaction resulting in the synthesis of nicotinate-adenine dinucleotide phosphate from NADP+. The switch between these two modes of catalysis is regulated by pH Homo sapiens ?
-
 ?
2.4.99.20 additional information enzymes cyclizes NAD to cADPR. In the presence of nicotinic acid, it catalyzes a base exchange reaction resulting in the synthesis of nicotinate-adenine dinucleotide phosphate from NADP+. The switch between these two modes of catalysis is regulated by pH Aplysia californica ?
-
 ?
2.4.99.20 NADP+
-
 Homo sapiens 2'-phospho-cyclic ADP-ribose + nicotinamide
-
 ?
2.4.99.20 NADP+
-
 Aplysia californica 2'-phospho-cyclic ADP-ribose + nicotinamide
-
 ?
2.4.99.20 NGDP+ enzyme cyclizes nicotinamide guanine dinucleotide to produce a fluorescent product, cyclic GDP-ribose, which has a site of cyclization different from cADPR Homo sapiens 2'-phospho-cyclic GDP-ribose + nicotinamide
-
 ?
2.4.99.20 NGDP+ enzyme cyclizes nicotinamide guanine dinucleotide to produce a fluorescent product, cyclic GDP-ribose, which has a site of cyclization different from cADPR Aplysia californica 2'-phospho-cyclic GDP-ribose + nicotinamide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.99.20 2'-phospho-cyclic-ADP-ribose transferase
-
 Homo sapiens
2.4.99.20 2'-phospho-cyclic-ADP-ribose transferase
-
 Aplysia californica
2.4.99.20 ADP-ribosyl cyclase 1
-
 Homo sapiens
2.4.99.20 ADP-ribosyl cyclase 1
-
 Aplysia californica
2.4.99.20 ADPRC 1
-
 Homo sapiens
2.4.99.20 CD38
-
 Homo sapiens