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Literature summary extracted from

  • Azmi, W.; Kumar, A.; Dev, V.
    Paraffin as oxygen vector modulates tyrosine phenol lyase production by Citrobacter freundii MTCC 2424 (2013), Acta Microbiol. Immunol. Hung., 60, 145-154.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.1.99.2 synthesis major applications of tyrosine phenol lyase in the production of L-tyrosine and L-DOPA. Tyrosine phenol lyase also has the ability to modify and synthesize natural and non-natural amino acids Citrobacter freundii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.99.2 L-3-4 dihydroxyphenylalanine + H2O Citrobacter freundii L-dopa catechol + pyruvate + NH3
-
 r
4.1.99.2 L-3-4 dihydroxyphenylalanine + H2O Citrobacter freundii MTCC 2424 L-dopa catechol + pyruvate + NH3
-
 r
4.1.99.2 L-tyrosine + H2O Citrobacter freundii alpha-beta elimination phenol + pyruvate + NH3
-
 r
4.1.99.2 L-tyrosine + H2O Citrobacter freundii MTCC 2424 alpha-beta elimination phenol + pyruvate + NH3
-
 r

Organism

EC Number Organism UniProt Comment Textmining
4.1.99.2 Citrobacter freundii
-
-
-
4.1.99.2 Citrobacter freundii MTCC 2424
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.99.2 additional information optimization and evaluation of cultivation conditions, overview Citrobacter freundii
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.99.2 L-3-4 dihydroxyphenylalanine + H2O L-dopa Citrobacter freundii catechol + pyruvate + NH3
-
 r
4.1.99.2 L-3-4 dihydroxyphenylalanine + H2O L-dopa Citrobacter freundii MTCC 2424 catechol + pyruvate + NH3
-
 r
4.1.99.2 L-tyrosine + H2O alpha-beta elimination Citrobacter freundii phenol + pyruvate + NH3
-
 r
4.1.99.2 L-tyrosine + H2O alpha-beta elimination Citrobacter freundii MTCC 2424 phenol + pyruvate + NH3
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.1.99.2 TPL
-
 Citrobacter freundii
4.1.99.2 tyrosine phenol lyase
-
 Citrobacter freundii

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.1.99.2 30
-
 assay at Citrobacter freundii

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.99.2 8.5
-
 assay at Citrobacter freundii

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.99.2 pyridoxal 5'-phosphate dependent on Citrobacter freundii

Expression

EC Number Organism Comment Expression
4.1.99.2 Citrobacter freundii L-tyrosine induces the enzyme, liquid paraffin as oxygen vector has a stimulatory effect on the enzyme synthesis up