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Literature summary extracted from

  • Molnari, J.; Myers, A.
    Carbonyl reduction of bupropion in human liver (2012), Xenobiotica, 42, 550-561.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.184 medicine antidepressant bupropion is reduced to erythrohydrobupropion and threohydrobupropion in liver. Menadione and 18beta-glycyrrhetinic acid are inhibitory Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.184 18beta-glycyrrhetinic acid inhibits the reduction of bupropion in liver microsomes Homo sapiens
1.1.1.184 menadione inhibits the reduction of bupropion in liver cytosol Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.184 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.184 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.184 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.184 bupropion + NADPH + H+
-
 Homo sapiens erythrohydrobupropion + NADP+ in liver cytosol, antidepressant bupropion is reduced to erythrohydrobupropion and threohydrobupropion ?
1.1.1.184 bupropion + NADPH + H+
-
 Homo sapiens threohydrobupropion + NADP+ in liver cytosol, antidepressant bupropion is reduced to erythrohydrobupropion and threohydrobupropion ?