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Literature summary extracted from
- New biotech applications from evolved D-amino acid oxidases (2011), Trends Biotechnol., 29, 276-283.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.4.3.3 | industry | the enzyme is used as a biocatalyst for resolving racemic amino acid mixtures, as a tool for biosensing, and as a mechanism of herbicide resistance | Rhodotorula toruloides |
| 1.4.3.3 | industry | the enzyme is used as a biocatalyst for resolving racemic amino acid mixtures, as a tool for biosensing, and as a mechanism of herbicide resistance | Glutamicibacter protophormiae |
| 1.4.3.3 | medicine | the enzyme is a potential valuable tool for cancer treatments that exploit the production of H2O2 | Homo sapiens |
| 1.4.3.3 | medicine | the enzyme is a potential valuable tool for cancer treatments that exploit the production of H2O2 | Rhodotorula toruloides |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.4.3.3 | S19G/S120P/Q144R/K321M/A345V | the mutant possesses a 10fold lower KM,O2, thus resulting in dramatically increased activity at low O2 concentrations | Rhodotorula toruloides |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.3.3 | 3-hydroxyquinolin-2-(1H)-one | - |
Homo sapiens |  |
| 1.4.3.3 | 5-methylpyrazole-3-carboxylic acid | - |
Homo sapiens | |
| 1.4.3.3 | 6-chlorobenzo[d]isoxazol-3-ol | - |
Homo sapiens | |
| 1.4.3.3 | benzoate | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.4.3.3 | D-amino acid + H2O + O2 | Glutamicibacter protophormiae | - |
a 2-oxo carboxylate + NH3 + H2O2 | - |
ir | |
| 1.4.3.3 | D-amino acid + H2O + O2 | Homo sapiens | - |
2-oxocarboxylate + NH3 + H2O2 | - |
ir | |
| 1.4.3.3 | D-amino acid + H2O + O2 | [Candida] boidinii | - |
2-oxocarboxylate + NH3 + H2O2 | - |
ir | |
| 1.4.3.3 | D-amino acid + H2O + O2 | Rhodotorula toruloides | - |
2-oxocarboxylate + NH3 + H2O2 | - |
ir | |
| 1.4.3.3 | D-amino acid + H2O + O2 | Trigonopsis variabilis | - |
2-oxocarboxylate + NH3 + H2O2 | - |
ir | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.4.3.3 | Glutamicibacter protophormiae | - |
- |
- |
| 1.4.3.3 | Homo sapiens | - |
- |
- |
| 1.4.3.3 | Rhodotorula toruloides | - |
- |
- |
| 1.4.3.3 | Trigonopsis variabilis | - |
- |
- |
| 1.4.3.3 | [Candida] boidinii | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.4.3.3 | cephalosporin C + H2O + O2 | - |
Rhodotorula toruloides | 7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2 | - |
ir | |
| 1.4.3.3 | D-alanine + H2O + O2 | - |
Rhodotorula toruloides | pyruvate + NH3 + H2O2 | - |
ir | |
| 1.4.3.3 | D-amino acid + H2O + O2 | - |
Glutamicibacter protophormiae | a 2-oxo carboxylate + NH3 + H2O2 | - |
ir | |
| 1.4.3.3 | D-amino acid + H2O + O2 | - |
Homo sapiens | 2-oxocarboxylate + NH3 + H2O2 | - |
ir | |
| 1.4.3.3 | D-amino acid + H2O + O2 | - |
[Candida] boidinii | 2-oxocarboxylate + NH3 + H2O2 | - |
ir | |
| 1.4.3.3 | D-amino acid + H2O + O2 | - |
Rhodotorula toruloides | 2-oxocarboxylate + NH3 + H2O2 | - |
ir | |
| 1.4.3.3 | D-amino acid + H2O + O2 | - |
Trigonopsis variabilis | 2-oxocarboxylate + NH3 + H2O2 | - |
ir | |
| 1.4.3.3 | D-glufosinate + H2O + O2 | - |
Rhodotorula toruloides | ? | - |
ir | |
| 1.4.3.3 | D-methionine + H2O + O2 | - |
Glutamicibacter protophormiae | 2-oxo-4-methylthiobutyric acid + NH3 + H2O2 | - |
ir | |
| 1.4.3.3 | DL-2-naphthyl-alanine + H2O + O2 | - |
Rhodotorula toruloides | L-2-naphthyl-alanine + 2-naphthylpyruvic acid + NH3 + H2O2 | - |
ir | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.4.3.3 | D-amino acid oxidase | - |
Homo sapiens |
| 1.4.3.3 | D-amino acid oxidase | - |
[Candida] boidinii |
| 1.4.3.3 | D-amino acid oxidase | - |
Rhodotorula toruloides |
| 1.4.3.3 | D-amino acid oxidase | - |
Glutamicibacter protophormiae |
| 1.4.3.3 | D-amino acid oxidase | - |
Trigonopsis variabilis |
| 1.4.3.3 | DAAO | - |
Homo sapiens |
| 1.4.3.3 | DAAO | - |
[Candida] boidinii |
| 1.4.3.3 | DAAO | - |
Rhodotorula toruloides |
| 1.4.3.3 | DAAO | - |
Glutamicibacter protophormiae |
| 1.4.3.3 | DAAO | - |
Trigonopsis variabilis |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.3.3 | FAD | - |
Homo sapiens | |
| 1.4.3.3 | FAD | - |
[Candida] boidinii | |
| 1.4.3.3 | FAD | - |
Rhodotorula toruloides | |
| 1.4.3.3 | FAD | - |
Glutamicibacter protophormiae | |
| 1.4.3.3 | FAD | - |
Trigonopsis variabilis | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.4.3.3 | 0.000004 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-hydroxyquinolin-2-(1H)-one | |
| 1.4.3.3 | 0.00019 | - |
pH and temperature not specified in the publication | Homo sapiens | 6-chlorobenzo[d]isoxazol-3-ol | |
| 1.4.3.3 | 0.00091 | - |
pH and temperature not specified in the publication | Homo sapiens | 5-methylpyrazole-3-carboxylic acid | |
| 1.4.3.3 | 0.016 | - |
pH and temperature not specified in the publication | Homo sapiens | benzoate | |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.4.3.3 | Homo sapiens | enzyme activity and expression are increased in schizophrenia patients | up |
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Release 2023.1 (January 2023)
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