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Literature summary extracted from

  • Celik, H.; Kosar, M.; Arinc, E.
    In vitro effects of myricetin, morin, apigenin, (+)-taxifolin, (+)-catechin, (-)-epicatechin, naringenin and naringin on cytochrome b5 reduction by purified NADH-cytochrome b5 reductase (2013), Toxicology, 308, 34-40.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.2.2 (+)-taxifolin
-
Bos taurus
1.6.2.2 additional information enzyme inhibition by dietary flavonoids: inhibitor structure-activity analysis, overview. No inhibition by morin, apigenin, (+)-catechin, (-)-epicatechin, naringenin and naringin Bos taurus
1.6.2.2 myricetin noncompetitive versus NADH, non-linear relationship indicating non-Michaelis-Menten kinetic binding with respect to cytochrome b5 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.2.2 microsome
-
Bos taurus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.2.2 2 ferricytochrome b5 + NADH Bos taurus
-
2 ferrocytochrome b5 + NAD+ + H+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.6.2.2 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.6.2.2 native enzyme from liver Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.2.2 liver
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.2.2 2 ferricytochrome b5 + NADH
-
Bos taurus 2 ferrocytochrome b5 + NAD+ + H+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.6.2.2 NADH-cytochrome b5 reductase
-
Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.6.2.2 24 25 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.6.2.2 7.5
-
assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.2.2 NADH
-
Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.6.2.2 0.00021
-
myricetin versus NADH, pH 7.5, 24-25°C Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.6.2.2 0.00037
-
pH 7.5, 24-25°C Bos taurus myricetin
1.6.2.2 0.0098
-
pH 7.5, 24-25°C Bos taurus (+)-taxifolin