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Literature summary extracted from

  • Arellano, Y.; Bratoeff, E.; Garrido, M.; Soriano, J.; Heuze, Y.; Cabeza, M.
    New ester derivatives of dehydroepiandrosterone as 5alpha-reductase inhibitors (2011), Steroids, 76, 1241-1246.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 3beta-(3'-oxapentanoyloxy)-androst-5-en-17-one good in vitro inhibitory activity, but compound does not bind to the androgen receptors Homo sapiens
1.3.1.22 3beta-acetoxyandrost-5-en-17-one good in vitro inhibitory activity, but compound does not bind to the androgen receptors Homo sapiens
1.3.1.22 3beta-hexanoyloxyandrost-5-en-17-one good in vitro inhibitory activity, but compound does not bind to the androgen receptors Homo sapiens
1.3.1.22 dehydroepiandrosterone good in vitro inhibitory activity, but compound does not bind to the androgen receptors Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 prostate
-
 Homo sapiens
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.3.1.22 0.000000002
-
 pH 6.5, 37°C Homo sapiens 3beta-hexanoyloxyandrost-5-en-17-one
1.3.1.22 0.0000011
-
 pH 6.5, 37°C Homo sapiens 3beta-(3'-oxapentanoyloxy)-androst-5-en-17-one
1.3.1.22 0.0000052
-
 pH 6.5, 37°C Homo sapiens 3beta-acetoxyandrost-5-en-17-one
1.3.1.22 0.000025
-
 pH 6.5, 37°C Homo sapiens dehydroepiandrosterone