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Literature summary extracted from

  • Kaster, A.; Moll, J.; Parey, K.; Thauer, R.
    Coupling of ferredoxin and heterodisulfide reduction via electron bifurcation in hydrogenotrophic methanogenic archaea (2011), Proc. Natl. Acad. Sci. USA, 108, 2981-2986.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.8.98.5 potassium phosphate complex is most active in presence of 1.6 M potassium phosphate Methanothermobacter marburgensis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.98.5 cytoplasm
-
Methanothermobacter marburgensis 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.7.12 formylmethanofuran + H2O + oxidized ferredoxin [iron-sulfur] cluster Methanothermobacter marburgensis
-
CO2 + methanofuran + reduced ferredoxin [iron-sulfur] cluster
-
?
1.2.7.12 formylmethanofuran + H2O + oxidized ferredoxin [iron-sulfur] cluster Methanothermobacter marburgensis DSM 2133
-
CO2 + methanofuran + reduced ferredoxin [iron-sulfur] cluster
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.2.7.12 Methanothermobacter marburgensis
-
-
-
1.2.7.12 Methanothermobacter marburgensis DSM 2133
-
-
-
1.8.98.5 Methanothermobacter marburgensis Q50754 subunit HrdC
-
1.8.98.5 Methanothermobacter marburgensis Q50755 subunit HrdB
-
1.8.98.5 Methanothermobacter marburgensis Q50756 subunit HrdA
-
1.8.98.5 Methanothermobacter marburgensis DSM 2133 Q50754 subunit HrdC
-
1.8.98.5 Methanothermobacter marburgensis DSM 2133 Q50755 subunit HrdB
-
1.8.98.5 Methanothermobacter marburgensis DSM 2133 Q50756 subunit HrdA
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.8.98.5 110
-
HdrABC complex with 100% H2 in the gas phase, pH 7.6, 60°C Methanothermobacter marburgensis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.7.12 formylmethanofuran + H2O + oxidized ferredoxin [iron-sulfur] cluster
-
Methanothermobacter marburgensis CO2 + methanofuran + reduced ferredoxin [iron-sulfur] cluster
-
?
1.2.7.12 formylmethanofuran + H2O + oxidized ferredoxin [iron-sulfur] cluster
-
Methanothermobacter marburgensis DSM 2133 CO2 + methanofuran + reduced ferredoxin [iron-sulfur] cluster
-
?
1.8.98.5 coenzyme B-coenzyme M disulfide + ferredoxin + 2 H2 HdrABC catalyzes the CoM-S-S-CoB-dependent reduction of ferredoxin with H2, coupling the endergonic reduction of ferredoxin to the exergonic reduction of coenzyme B-coenzyme M disulfide. Per mole CoM-S-S-CoB added, 1 mol of ferredoxin is reduced, indicating an electron bifurcation coupling mechanism. The stoichiometry of coupling is consistent with an ATP gain per mole methane from 4 H2 and CO2 of near 0.5 Methanothermobacter marburgensis coenzyme B + coenzyme M + reduced ferredoxin2- + 2 H+
-
?
1.8.98.5 coenzyme B-coenzyme M disulfide + ferredoxin + 2 H2 HdrABC catalyzes the CoM-S-S-CoB-dependent reduction of ferredoxin with H2, coupling the endergonic reduction of ferredoxin to the exergonic reduction of coenzyme B-coenzyme M disulfide. Per mole CoM-S-S-CoB added, 1 mol of ferredoxin is reduced, indicating an electron bifurcation coupling mechanism. The stoichiometry of coupling is consistent with an ATP gain per mole methane from 4 H2 and CO2 of near 0.5 Methanothermobacter marburgensis DSM 2133 coenzyme B + coenzyme M + reduced ferredoxin2- + 2 H+
-
?
1.8.98.5 coenzyme B-coenzyme M disulfide + metronidazole + 2 H2 purified complex shows a twofold higher specific activity with ferredoxin than with metronidazole Methanothermobacter marburgensis coenzyme B + coenzyme M + reduced metronidazole2- + 2 H+
-
?
1.8.98.5 coenzyme B-coenzyme M disulfide + metronidazole + 2 H2 purified complex shows a twofold higher specific activity with ferredoxin than with metronidazole Methanothermobacter marburgensis DSM 2133 coenzyme B + coenzyme M + reduced metronidazole2- + 2 H+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.2.7.12 formyl-methanofuran dehydrogenase
-
Methanothermobacter marburgensis
1.2.7.12 FwdA-DFGH/FwdAFmdBCE
-
Methanothermobacter marburgensis
1.8.98.5 HdrA
-
Methanothermobacter marburgensis
1.8.98.5 HdrABC
-
Methanothermobacter marburgensis
1.8.98.5 HdrB
-
Methanothermobacter marburgensis
1.8.98.5 HdrC
-
Methanothermobacter marburgensis
1.8.98.5 MvhADG
-
Methanothermobacter marburgensis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.8.98.5 70
-
-
Methanothermobacter marburgensis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.8.98.5 7.5
-
-
Methanothermobacter marburgensis