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Literature summary extracted from

  • Cole, G.B.; Keum, G.; Liu, J.; Small, G.W.; Satyamurthy, N.; Kepe, V.; Barrio, J.R.
    Specific estrogen sulfotransferase (SULT1E1) substrates and molecular imaging probe candidates (2010), Proc. Natl. Acad. Sci. USA, 107, 6222-6227.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.4 expressed in Sf9 insect cells Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.4 0.000006
-
 17beta-estradiol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
2.8.2.4 0.00012
-
 2-(4-nitrophenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
2.8.2.4 0.00025
-
 2-(4-cyanophenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
2.8.2.4 0.00043
-
 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
2.8.2.4 0.00052
-
 2-(4-iodophenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
2.8.2.4 0.00056
-
 2-(4-fluorophenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
2.8.2.4 0.00077
-
 2-(4-methylaminophenyl)-1,3-benzothiazol-5-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
2.8.2.4 0.0009
-
 2-(4-methoxyphenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
2.8.2.4 0.00099
-
 2-phenyl-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
2.8.2.4 0.001
-
 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
2.8.2.4 0.00132
-
 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
2.8.2.4 0.00142
-
 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
2.8.2.4 0.00142
-
 2-(4-methylaminophenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
2.8.2.4 0.00211
-
 2-(4-aminophenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
2.8.2.4 0.00236
-
 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
2.8.2.4 0.00591
-
 2-naphthol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.4 3'-phosphoadenylyl sulfate + 1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine-3',5'-bisphosphate + 1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 1,3-benzoxazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 1,3-benzoxazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 1-benzofuran-5-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 1-benzofuran-5-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 1-benzofuran-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 1-benzofuran-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 1-benzothiophene-5-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 1-benzothiophene-5-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 1-benzothiophene-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 1-benzothiophene-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 17beta-estradiol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 1H-indol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 1H-indol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-aminophenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-aminophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-cyanophenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-cyanophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-fluorophenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-fluorophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-iodophenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-iodophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-methoxyphenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-methoxyphenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-methylaminophenyl)-1,3-benzothiazol-5-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-methylaminophenyl)-1,3-benzothiazol-5-yl suflate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-methylaminophenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-methylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-nitrophenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-nitrophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-methyl-1,3-benzothiazol-5-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-methyl-1,3-benzothiazol-5-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-methyl-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-methyl-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-naphthol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-phenyl-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-phenyl-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-yl sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.4 brain the majority of the SULT1E1 activity is observed in the frontal cortical area, superior cortical areas, subcortical areas, and brain stem Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.4 3'-phosphoadenylyl sulfate + 1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine-3',5'-bisphosphate + 1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 1,3-benzoxazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1,3-benzoxazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 1-benzofuran-5-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-benzofuran-5-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 1-benzofuran-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-benzofuran-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 1-benzothiophene-5-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-benzothiophene-5-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 1-benzothiophene-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-benzothiophene-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 17beta-estradiol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 1H-indol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1H-indol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-aminophenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-aminophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-cyanophenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-cyanophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-fluorophenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-fluorophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-iodophenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-iodophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-methoxyphenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-methoxyphenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-methylaminophenyl)-1,3-benzothiazol-5-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-methylaminophenyl)-1,3-benzothiazol-5-yl suflate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-methylaminophenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-methylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-(4-nitrophenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-nitrophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-methyl-1,3-benzothiazol-5-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-methyl-1,3-benzothiazol-5-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-methyl-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-methyl-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-naphthol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-phenyl-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-phenyl-1,3-benzothiazol-6-yl sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-yl sulfate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.4 EST
-
 Rattus norvegicus
2.8.2.4 estrogen sulfotransferase
-
 Rattus norvegicus
2.8.2.4 SULT1E1
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
2.8.2.4 physiological function SULT1E1 is a key enzyme in estrogen homeostasis Rattus norvegicus