EC Number | Application | Comment | Organism |
---|---|---|---|
1.3.8.6 | pharmacology | targeted suppression of GCDH by lentivirus-mediated shRNA and excessive intake of lysine may be a useful cell model of glutaric aciduria type 1, overview | Rattus norvegicus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.3.8.6 | additional information | constructionof a lentiviral vector containing short hairpin RNA targeted against the GCDH gene expression (lentivirus-shRNA) in neurons | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.8.6 | glutaryl-CoA + FAD | Rattus norvegicus | - |
(E)-but-2-enoyl-CoA + CO2 + FADH2 | - |
? | |
1.3.8.6 | glutaryl-CoA + FAD | Rattus norvegicus Sprague-Dawley | - |
(E)-but-2-enoyl-CoA + CO2 + FADH2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.8.6 | Rattus norvegicus | - |
- |
- |
1.3.8.6 | Rattus norvegicus Sprague-Dawley | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.3.8.6 | neuron | striatal, from neonatal rats | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.8.6 | glutaryl-CoA + FAD | - |
Rattus norvegicus | (E)-but-2-enoyl-CoA + CO2 + FADH2 | - |
? | |
1.3.8.6 | glutaryl-CoA + FAD | - |
Rattus norvegicus Sprague-Dawley | (E)-but-2-enoyl-CoA + CO2 + FADH2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.3.8.6 | GCDH | - |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.3.8.6 | FAD | - |
Rattus norvegicus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.3.8.6 | malfunction | in glutaric aciduria type 1, glutaryl-CoA dehydrogenase deficiency is responsible for the accumulation of glutaric acid and striatal degeneration, GA1-induced striatal degeneration is partially caspase-dependent, mechanism, overview | Rattus norvegicus |