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Literature summary extracted from

  • Gao, J.; Zhang, C.; Fu, X.; Yi, Q.; Tian, F.; Ning, Q.; Luo, X.
    Effects of targeted suppression of glutaryl-CoA dehydrogenase by lentivirus-mediated shRNA and excessive intake of lysine on apoptosis in rat striatal neurons (2013), PLoS ONE, 8, e63084.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.3.8.6 pharmacology targeted suppression of GCDH by lentivirus-mediated shRNA and excessive intake of lysine may be a useful cell model of glutaric aciduria type 1, overview Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
1.3.8.6 additional information constructionof a lentiviral vector containing short hairpin RNA targeted against the GCDH gene expression (lentivirus-shRNA) in neurons Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.8.6 glutaryl-CoA + FAD Rattus norvegicus
-
(E)-but-2-enoyl-CoA + CO2 + FADH2
-
?
1.3.8.6 glutaryl-CoA + FAD Rattus norvegicus Sprague-Dawley
-
(E)-but-2-enoyl-CoA + CO2 + FADH2
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.3.8.6 Rattus norvegicus
-
-
-
1.3.8.6 Rattus norvegicus Sprague-Dawley
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.8.6 neuron striatal, from neonatal rats Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.8.6 glutaryl-CoA + FAD
-
Rattus norvegicus (E)-but-2-enoyl-CoA + CO2 + FADH2
-
?
1.3.8.6 glutaryl-CoA + FAD
-
Rattus norvegicus Sprague-Dawley (E)-but-2-enoyl-CoA + CO2 + FADH2
-
?

Synonyms

EC Number Synonyms Comment Organism
1.3.8.6 GCDH
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.8.6 FAD
-
Rattus norvegicus

General Information

EC Number General Information Comment Organism
1.3.8.6 malfunction in glutaric aciduria type 1, glutaryl-CoA dehydrogenase deficiency is responsible for the accumulation of glutaric acid and striatal degeneration, GA1-induced striatal degeneration is partially caspase-dependent, mechanism, overview Rattus norvegicus