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Literature summary extracted from

  • Yang, X.; Xu, Y.; Guo, F.; Ning, Y.; Zhi, X.; Yin, L.; Li, X.
    Hydroxysteroid sulfotransferase SULT2B1b promotes hepatocellular carcinoma cells proliferation in vitro and in vivo (2013), PLoS ONE, 8, e60853.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.2 expressed in the mouse hepatocarcinoma cell line Hepa1-6 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.2 cytosol
-
 Homo sapiens 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.2.15 41000
-
 x * 41000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.15 3'-phosphoadenylylsulfate + cholesterol Homo sapiens
-
 adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.2 Homo sapiens O00204
-
-
2.8.2.15 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.2 BEL-7402 cell
-
 Homo sapiens
-
2.8.2.2 HEP-3B cell
-
 Homo sapiens
-
2.8.2.2 hepatocellular carcinoma cell
-
 Homo sapiens
-
2.8.2.2 Huh-7 cell
-
 Homo sapiens
-
2.8.2.2 SMMC-7721 cell
-
 Homo sapiens
-
2.8.2.15 BEL-7402 cell
-
 Homo sapiens
-
2.8.2.15 HEP-3B cell
-
 Homo sapiens
-
2.8.2.15 HEPA 1-6 cell
-
 Homo sapiens
-
2.8.2.15 hepatocarcinoma cell
-
 Homo sapiens
-
2.8.2.15 Huh-7 cell
-
 Homo sapiens
-
2.8.2.15 SMMC-7721 cell highest expression Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.2 3'-phosphoadenylylsulfate + cholesterol
-
 Homo sapiens adenosine 3',5'-bisphosphate + cholesterol sulfate
-
 ?
2.8.2.15 3'-phosphoadenylylsulfate + cholesterol
-
 Homo sapiens adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.8.2.15 ? x * 41000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.8.2.2 hydroxysteroid sulfotransferase
-
 Homo sapiens
2.8.2.2 SULT2B1b
-
 Homo sapiens
2.8.2.15 hydroxysteroid sulfotransferase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.8.2.15 Homo sapiens inhibition of SULT2B1b expression induces cell-cycle arrest and apoptosis in Hepa1-6 cells by upregulating the expression of FAS, downregulating the expression of cyclinB1, BCL2 and MYC in vitro and in vivo at both the transcript and protein levels. Knock-down of SULT2B1b expression significantly suppresses tumor growth in nude mouse xenografts down
2.8.2.15 Homo sapiens SULT2B1 is comparatively higher in the human hepatocarcinoma tumorous tissues than their adjacent tissues up

General Information

EC Number General Information Comment Organism
2.8.2.2 malfunction knock-down of SULT2B1b inhibits cell growth and cyclinB1 levels in human hepatocarcinoma cells and suppressed xenograft growth in vivo Homo sapiens
2.8.2.2 physiological function SULT2B1b expression promotes proliferation of hepatocellular carcinoma cells in vitro and in vivo, which may contribute to the progression of hepatocellular carcinoma Homo sapiens
2.8.2.15 malfunction knockdown of SULT2B1 in Hepa1-6 cells induces cell-cycle arrest and apoptosis and suppresses tumorigenesis in vivo Homo sapiens
2.8.2.15 physiological function SULT2B1b expression promotes proliferation of hepatocellular carcinoma cells in vitro and in vivo, which may contribute to the progression of hepatocellular carcinoma Homo sapiens