Literature summary extracted from

Edwards, C.; Copes, N.; Brito, A.; Canfield, J.; Bradshaw, P.
Malate and fumarate extend lifespan in Caenorhabditis elegans (2013), PLoS ONE, 8, e58345.

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.3.1.6	Caenorhabditis elegans	-	-	-

General Information

EC Number	General Information	Comment	Organism
1.3.1.6	physiological function	the increased longevity of worms provided by malate addition does not occur in fumarase fum-1, glyoxylate shunt gei-7, succinate dehydrogenase flavoprotein sdha-2, or soluble fumarate reductase F48E8.3 RNAi knockdown worms. Therefore, to increase lifespan, malate must be first converted to fumarate, then fumarate must be reduced to succinate by soluble fumarate reductase and the mitochondrial electron transport chain complex II. Fumarate reduction, glyoxylate shunt activity, and mild mitochondrial uncoupling likely contribute to the lifespan extension induced by malate and fumarate by increasing the amount of oxidized NAD and FAD cofactors	Caenorhabditis elegans

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)