EC Number | Application | Comment | Organism |
---|---|---|---|
1.1.1.146 | medicine | curcumin is inhibitory to isoform 11beta-HSD1 in intact cells with IC50 value of 5.79 microM, competitive. Treatment with curcumin reduces serum glucose, cholesterol, triglyceride, low density lipoprotein levels in high-fat-diet-induced obese rats | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.B40 | curcumin | inhibitory against isoform 11beta-HSD2 in intact cells with IC50 value of 14.56 microM | Homo sapiens | |
1.1.1.146 | (1E,4E)-1,5-bis(thiophen-2-yl) penta-1,4-dien-3-one | derivative of curcumin, IC50 value in intact cells 93 nM. Not inhibitory to isoform 11beta-HSD2 in kidney at 100 microM | Homo sapiens | |
1.1.1.146 | (1E,4E)-1,5-bis(thiophen-2-yl) penta-1,4-dien-3-one | derivative of curcumin, IC50 value in intact cells 184 nM. Not inhibitory to isoform 11beta-HSD2 in kidney at 100 microM | Rattus norvegicus | |
1.1.1.146 | curcumin | inhibitory against isoform 11beta-HSD1 in intact cells with IC50 value of 2.29 microM | Homo sapiens | |
1.1.1.146 | curcumin | inhibitory against isoform 11beta-HSD1 in intact cells with IC50 value of 5.79 microM, competitive. Treatment with curcumin reduces serum glucose, cholesterol, triglyceride, low density lipoprotein levels in high-fat-diet-induced obese rats | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.B40 | Homo sapiens | P80365 | isoform 11beta-HSD2 | - |
1.1.1.146 | Homo sapiens | P28845 | - |
- |
1.1.1.146 | Rattus norvegicus | P16232 | - |
- |