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Literature summary extracted from

  • Hu, G.; Lin, H.; Lian, Q.; Zhou, S.; Guo, J.; Zhou, H.; Chu, Y.; Ge, R.
    Curcumin as a potent and selective inhibitor of 11beta-hydroxysteroid dehydrogenase 1: improving lipid profiles in high-fat-diet-treated rats (2013), PLoS ONE, 8, e49976.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.1.1.146 medicine curcumin is inhibitory to isoform 11beta-HSD1 in intact cells with IC50 value of 5.79 microM, competitive. Treatment with curcumin reduces serum glucose, cholesterol, triglyceride, low density lipoprotein levels in high-fat-diet-induced obese rats Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.B40 curcumin inhibitory against isoform 11beta-HSD2 in intact cells with IC50 value of 14.56 microM Homo sapiens
1.1.1.146 (1E,4E)-1,5-bis(thiophen-2-yl) penta-1,4-dien-3-one derivative of curcumin, IC50 value in intact cells 93 nM. Not inhibitory to isoform 11beta-HSD2 in kidney at 100 microM Homo sapiens
1.1.1.146 (1E,4E)-1,5-bis(thiophen-2-yl) penta-1,4-dien-3-one derivative of curcumin, IC50 value in intact cells 184 nM. Not inhibitory to isoform 11beta-HSD2 in kidney at 100 microM Rattus norvegicus
1.1.1.146 curcumin inhibitory against isoform 11beta-HSD1 in intact cells with IC50 value of 2.29 microM Homo sapiens
1.1.1.146 curcumin inhibitory against isoform 11beta-HSD1 in intact cells with IC50 value of 5.79 microM, competitive. Treatment with curcumin reduces serum glucose, cholesterol, triglyceride, low density lipoprotein levels in high-fat-diet-induced obese rats Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Homo sapiens P80365 isoform 11beta-HSD2
-
1.1.1.146 Homo sapiens P28845
-
-
1.1.1.146 Rattus norvegicus P16232
-
-