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Literature summary extracted from

  • Satoh, M.; Haruta-Satoh, E.; Yamada, M.; Kado, S.; Nomura, F.
    Overexpression of hydroxymethylglutaryl CoA synthase 2 and 2,4-dienoyl-CoA reductase in rat pancreas following chronic alcohol consumption (2013), Pancreas, 42, 475-482.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.3.10 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA Rattus norvegicus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.124 Rattus norvegicus
-
-
-
2.3.3.10 Rattus norvegicus P22791
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.124 pancreas
-
 Rattus norvegicus
-
2.3.3.10 pancreas
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA
-
 Rattus norvegicus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.124 2,4-dienoyl-CoA reductase
-
 Rattus norvegicus
2.3.3.10 HMGCS2
-
 Rattus norvegicus
2.3.3.10 hydroxymethylglutaryl CoA synthase 2
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.3.1.124 Rattus norvegicus expression of 2,4-dienoyl-CoA reductase is up-regulated in pancreas of alcohol-fed rats up
2.3.3.10 Rattus norvegicus the enzyme activity is higher in alcohol-fed rats, but the relative increase in enzyme activity in alcohol-fed rats is less than the relative increase in enzyme expression up