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Literature summary extracted from

  • Hou, Q.; Jiang, H.; Zhang, X.; Guo, C.; Huang, B.; Wang, P.; Wang, T.; Wu, K.; Li, J.; Gong, Z.; Du, L.; Liu, Y.; Liu, L.; Chen, C.
    Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila (2011), Nitric Oxide, 24, 17-24.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.284 overexpression of the fdh in the central nervous system of transgenic Drosophila melanogaster Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.284 additional information overexpression of the fdh in the central nervous system significantly increases GSNOR activity and induces visual pattern memory defects of Drosophila melanogaster, Overexpression of fdh results in NO imbalance, thereby affecting the NO-cGMPPKG pathway and protein S-nitrosation and, ultimately, learning and memory function, regulation of protein S-nitrosation by fdh in transgenic flies, overview. elav-Gal4 driven pan-neuronal GSNOR and PKG co-expression flies restore normal memory performance completely Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.284 S-nitrosoglutathione + NADH Drosophila melanogaster
-
 ? + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.284 Drosophila melanogaster
-
 gene fdh
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.284 brain GSNOR is the sole alcohol dehydrogenase isozyme in vertebrate brains Drosophila melanogaster
-
1.1.1.284 neuron
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.284 S-nitrosoglutathione + NADH
-
 Drosophila melanogaster ? + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.284 FDH
-
 Drosophila melanogaster
1.1.1.284 formaldehyde dehydrogenase
-
 Drosophila melanogaster
1.1.1.284 GSNOR
-
 Drosophila melanogaster

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.284 25
-
 assay at Drosophila melanogaster

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.284 7.5
-
 assay at Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.284 NADH
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
1.1.1.284 malfunction overexpression of the fdh in the central nervous system significantly increases GSNOR activity and induces visual pattern memory defects of Drosophila melanogaster. Overexpression of the fdh in the fan-shaped body induces memory defect, while overexpression in the mushroom body does not. The visual pattern memory defect can be rescued by co-expression with exogenous cGMP-dependent protein kinase Drosophila melanogaster
1.1.1.284 physiological function the enzyme controls the nitric oxide metabolism, which plays a crucial role in visual pattern memory in Drosophila melanogaster. The role of fdh in learning and memory is independent of development and is neuron-specific Drosophila melanogaster