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Literature summary extracted from
- Lipoamide dehydrogenase is essential for both bloodstream and procyclic Trypanosoma brucei (2011), Mol. Microbiol., 81, 623-639.
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.4 | Trypanosoma brucei | - |
- |
- |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.4 | LipDH | - |
Trypanosoma brucei |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.8.1.4 | physiological function | RNA interference or the deletion of both alleles of lipoamide dehydrogenase in bloodstream Trypanosoma brucei results in an absolute requirement for exogenous thymidine. In the absence of thymidine, lipdh-/- parasites show a severely altered morphology and cell cycle distribution. Lipdh-/- cells are unable to infect mice. Degradation of branched-chain amino acids takes place but is dispensable. In cultured bloodstream - but not procyclic - African trypanosomes, the total cellular concentration of lipoamide dehydrogenase increases with increasing cell densities. In procyclic parasites, lipoamide dehydrogenasemRNA depletion causes an even stronger proliferation defect that is not reversed by presence of thymidine | Trypanosoma brucei |
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Release 2023.1 (January 2023)
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