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Literature summary extracted from

  • Gonzalez-Guerrero, M.; Raimunda, D.; Cheng, X.; Argueello, J.M.
    Distinct functional roles of homologous Cu+ efflux ATPases in Pseudomonas aeruginosa (2010), Mol. Microbiol., 78, 1246-1258.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.2.2.8 expressed in Escherichia coli DC194 cells Pseudomonas aeruginosa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.8 membrane
-
 Pseudomonas aeruginosa 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.8 ATP + H2O + Cu+[side 1] Pseudomonas aeruginosa
-
 ADP + phosphate + Cu+[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.8 Pseudomonas aeruginosa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
7.2.2.8 phosphoprotein
-
 Pseudomonas aeruginosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.8 ATP + H2O + Cu+[side 1]
-
 Pseudomonas aeruginosa ADP + phosphate + Cu+[side 2]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.8 CopA1 isoform Pseudomonas aeruginosa
7.2.2.8 CopA2 isoform Pseudomonas aeruginosa
7.2.2.8 Cu+-ATPase
-
 Pseudomonas aeruginosa

General Information

EC Number General Information Comment Organism
7.2.2.8 malfunction mutation of isoform CopA2 has no effect on Cu toxicity nor intracellular Cu levels but it leads to higher H2O2 sensitivity and reduced cytochrome oxidase activity Pseudomonas aeruginosa
7.2.2.8 physiological function Isoforms CopA1 and CopA2 catalyse cytoplasmic Cu+ efflux into the periplasm. Isoforms CopA1 and CopA2 are essential for virulence. Isoform CopA1 maintains the cellular Cu quota and provides tolerance to this metal Pseudomonas aeruginosa