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Literature summary extracted from

  • Reniere, M.L.; Skaar, E.P.
    Staphylococcus aureus haem oxygenases are differentially regulated by iron and haem (2008), Mol. Microbiol., 69, 1304-1315.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.48 Staphylococcus aureus Q7A649
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1.14.99.48 Staphylococcus aureus Q7A827 isoform IsdI
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1.14.99.48 Staphylococcus aureus N315 Q7A649
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1.14.99.48 Staphylococcus aureus N315 Q7A827 isoform IsdI
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General Information

EC Number General Information Comment Organism
1.14.99.48 physiological function isoforms IsdG and IsdI are both important for Staphylococcus aureus growth on haemin as a sole iron source and are necessary for full Staphylococcus aureus pathogenesis. Strains lacking IsdG, IsdI or both exhibit significantly impaired growth on hemin as a sole iron source when compared with wild-type. Inactivation of IsdG and IsdI in combination does not enhance the hemin utilization defect over that of either individual mutant strain. Overexpression of either IsdG or IsdI complements the loss of both enzymes, and expression of IsdG and IsdI is regulated by iron in a Fur-dependent manner and differentially regulated by iron and hemin Staphylococcus aureus
1.14.99.48 physiological function isoforms IsdG and IsdI are both important for Staphylococcus aureus growth on haemin as a sole iron source and are necessary for full Staphylococcus aureus pathogenesis. Strains lacking IsdG, IsdI or both exhibit significantly impaired growth on hemin as a sole iron source when compared with wild-type. Inactivation of IsdG and IsdI in combination does not enhance the hemin utilization defect over that of either individual mutant strain. Overexpression of either IsdG or IsdI complements the loss of both enzymes, and expression of IsdG and IsdI is regulated by iron in a Fur-dependent manner and differentially regulated by iron and hemin. Hemin-dependent upregulation of IsdG is occurring post-transcriptionally by enhancing its protein stability Staphylococcus aureus