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Literature summary extracted from

  • Ou, Z.; Shi, X.; Gilroy, R.K.; Kirisci, L.; Romkes, M.; Lynch, C.; Wang, H.; Xu, M.; Jiang, M.; Ren, S.; Gramignoli, R.; Strom, S.C.; Huang, M.; Xie, W.
    Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORalpha and RORgamma and its potential relevance to human liver diseases (2013), Mol. Endocrinol., 27, 106-115.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.15 3'-phosphoadenylylsulfate + dehydroepiandrosterone Homo sapiens
-
 adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.15 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.15 Hep-G2 cell
-
 Homo sapiens
-
2.8.2.15 hepatocyte
-
 Homo sapiens
-
2.8.2.15 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.15 3'-phosphoadenylylsulfate + dehydroepiandrosterone
-
 Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.15 hydroxysteroid sulfotransferase
-
 Homo sapiens
2.8.2.15 SULT2A1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.8.2.15 Homo sapiens down-regulation of RORalpha and/or RORgamma by small interfering RNA inhibits the expression of endogenous SULT2A1 down
2.8.2.15 Homo sapiens retinoid-related orphan receptor (ROR)alpha and RORgamma transactivate the SULT2A1 gene promoter through their binding to a ROR response element found in the SULT2A1 gene promoter up