EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.14.11.4 | Fe2+ | dependent on | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.11.4 | L-lysine-[procollagen] + 2-oxoglutarate + O2 | Homo sapiens | - |
(2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2 | - |
? | |
1.14.11.4 | additional information | Homo sapiens | JMJD6 undergoes self-hydroxylation in the presence of Fe(II) and 2-oxoglutarate, in absence of substrate or in presence of substrates like U2AF65, resulting in production of (5S)<-hydroxylysine residues. JMJD6 in human cells is hydroxylated | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.11.4 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.11.4 | L-lysine-[procollagen] + 2-oxoglutarate + O2 | - |
Homo sapiens | (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2 | - |
? | |
1.14.11.4 | additional information | JMJD6 undergoes self-hydroxylation in the presence of Fe(II) and 2-oxoglutarate, in absence of substrate or in presence of substrates like U2AF65, resulting in production of (5S)<-hydroxylysine residues. JMJD6 in human cells is hydroxylated | Homo sapiens | ? | - |
? | |
1.14.11.4 | additional information | in absence of substrate JMJD6 catalyses turnover of 2-oxoglutarate to succinate | Homo sapiens | ? | - |
? | |
1.14.11.4 | U2AF65 + 2-oxoglutarate + O2 | - |
Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.11.4 | Jmjd6 | - |
Homo sapiens |
1.14.11.4 | lysyl 5S-hydroxylase | - |
Homo sapiens |
1.14.11.4 | lysyl hydroxylase | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.14.11.4 | physiological function | the lysyl 5S-hydroxylase, JMJD6 acts on proteins involved in RNA splicin. JMJD6 in human cells is self-hydroxylated at Lys111JMJD6 and Lys167JMJD6 to give lysyl 5S-hydroxylase. Self-hydroxylation of JMJD6 may play a regulatory role in modulating the hydroxylation status of proteins involved in RNA splicing | Homo sapiens |