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Literature summary extracted from

  • Silva, P.J.; Ramos, M.J.
    Computational characterization of the substrate-binding mode in coproporphyrinogen III oxidase (2011), J. Phys. Chem. B, 115, 1903-1910.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.3.3.3 D274A site-directed mutagensis, inactive mutant Saccharomyces cerevisiae
1.3.3.3 H131A site-directed mutagensis, inactive mutant Saccharomyces cerevisiae
1.3.3.3 R135A site-directed mutagensis, inactive mutant Saccharomyces cerevisiae
1.3.3.3 R275A site-directed mutagensis, inactive mutant Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.3 coproporphyrinogen III + O2 + 2 H+ Saccharomyces cerevisiae
-
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.3 Saccharomyces cerevisiae
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.3.3.3 coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O reaction mechanism, substrate docking study and binding mode, involving residues H131, R135, D274, and R275, and active site analysis using crystal structures, molecular dynamics simulations, overview. Selectivity of the active site, formed by His131, Asn133, and Ser117, toward substituted tetrapyrroles, nonoccurrence of catalysis on the C and D rings of the tetrapyrrole. The carbonyl oxygen of G276 intervenes in the substrate anchoring by hydrogen bonding of the ring D pyrrole NH group. The pyrrole ring is very unlikely to undergo deprotonation during the catalytic cycle Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.3 coproporphyrinogen III + O2 + 2 H+
-
Saccharomyces cerevisiae protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
?

Subunits

EC Number Subunits Comment Organism
1.3.3.3 dimer
-
Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
1.3.3.3 oxygen-dependent coproporphyrinogen III oxidase
-
Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
1.3.3.3 metabolism oxygen-dependent coproporphyrinogen III oxidase catalyzes the sequential decarboxylation of the propionate substituents present on the A and B rings of coproporphyrinogen III in the heme biosynthetic pathway Saccharomyces cerevisiae