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Literature summary extracted from

  • Pedone, E.; D'Ambrosio, K.; De Simone, G.; Rossi, M.; Pedone, C.; Bartolucci, S.
    Insights on a new PDI-like family: structural and functional analysis of a protein disulfide oxidoreductase from the bacterium Aquifex aeolicus (2005), J. Mol. Biol., 356, 155-164.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.99.B1 mutant enzymes C34S, C148S and C34S/C148S, are overexpressed in Escherichia coli Aquifex aeolicus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.8.99.B1 crystal structure at 2.4 A resolution Aquifex aeolicus

Protein Variants

EC Number Protein Variants Comment Organism
1.8.99.B1 C148S mutant enzyme exhibits a lower activity compared to wild-type enzyme Aquifex aeolicus
1.8.99.B1 C34S mutant enzyme retains nearly wild-type activity Aquifex aeolicus
1.8.99.B1 C34S/C148S mutant enzyme shows no activity Aquifex aeolicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.8.99.B1 26700
-
gel-filtration, electrospray mass spectroscopy Aquifex aeolicus

Organism

EC Number Organism UniProt Comment Textmining
1.8.99.B1 Aquifex aeolicus O66753
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.99.B1 wild-type enzyme and recombinant mutant enzymes C34S, C148S and C34S/C148S Aquifex aeolicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.99.B1 additional information the enzyme reveals an inherent glutathione-dependent thioltransferase activity Aquifex aeolicus ?
-
?
1.8.99.B1 [insulin]-disulfide + reduced dithiothreitol
-
Aquifex aeolicus [insulin]-dithiol + oxidized dithiothreitol
-
?

Synonyms

EC Number Synonyms Comment Organism
1.8.99.B1 AaPDO
-
Aquifex aeolicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.8.99.B1 30
-
assay at Aquifex aeolicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.8.99.B1 7
-
assay at Aquifex aeolicus