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Literature summary extracted from

  • Kwon, Y.J.; Sohn, M.J.; Oh, T.; Cho, S.N.; Kim, C.J.; Kim, W.G.
    Panosialins, inhibitors of enoyl-ACP reductase from Streptomyces sp. AN1761 (2013), J. Microbiol. Biotechnol., 23, 184-188.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.9 panosialin A acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761, potently inhibits bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis Mycobacterium tuberculosis
1.3.1.9 panosialin A acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761, potently inhibits bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis Streptococcus pneumoniae
1.3.1.9 panosialin B acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761, potently inhibits bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis Mycobacterium tuberculosis
1.3.1.9 panosialin B acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761, potently inhibits bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis Streptococcus pneumoniae
1.3.1.9 panosialin wA acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761, potently inhibits bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis Mycobacterium tuberculosis
1.3.1.9 panosialin wA acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761, potently inhibits bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis Streptococcus pneumoniae
1.3.1.9 panosialin wB acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761, potently inhibits bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis Mycobacterium tuberculosis
1.3.1.9 panosialin wB acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761, potently inhibits bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis Streptococcus pneumoniae
1.3.1.39 panosialin A acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761, potently inhibits bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis Staphylococcus aureus
1.3.1.39 panosialin B acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761, potently inhibits bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis Staphylococcus aureus
1.3.1.39 panosialin wA acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761, potently inhibits bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis Staphylococcus aureus
1.3.1.39 panosialin wB acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761, potently inhibits bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis Staphylococcus aureus
1.3.1.39 triclosan
-
 Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.9 Mycobacterium tuberculosis
-
-
-
1.3.1.9 Streptococcus pneumoniae
-
-
-
1.3.1.39 Staphylococcus aureus Q6GI75
-
-

Synonyms

EC Number Synonyms Comment Organism
1.3.1.9 FabI
-
 Streptococcus pneumoniae
1.3.1.9 InhA
-
 Mycobacterium tuberculosis
1.3.1.39 FabI
-
 Staphylococcus aureus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.3.1.9 0.0039
-
 pH 6.5, temperature not specified in the publication Streptococcus pneumoniae panosialin A
1.3.1.9 0.0052
-
 pH 6.5, temperature not specified in the publication Streptococcus pneumoniae panosialin B
1.3.1.9 0.0052
-
 pH 6.5, temperature not specified in the publication Streptococcus pneumoniae panosialin wA
1.3.1.9 0.0055
-
 pH 6.5, temperature not specified in the publication Streptococcus pneumoniae panosialin wB
1.3.1.9 0.0085
-
 pH 8.0, temperature not specified in the publication Mycobacterium tuberculosis panosialin B
1.3.1.9 0.0091
-
 pH 8.0, temperature not specified in the publication Mycobacterium tuberculosis panosialin wB
1.3.1.9 0.0096
-
 pH 8.0, temperature not specified in the publication Mycobacterium tuberculosis panosialin wA
1.3.1.9 0.0118
-
 pH 8.0, temperature not specified in the publication Mycobacterium tuberculosis panosialin A
1.3.1.39 0.00066
-
 pH 6.5, temperature not specified in the publication Staphylococcus aureus triclosan
1.3.1.39 0.003
-
 pH 6.5, temperature not specified in the publication Staphylococcus aureus panosialin wA
1.3.1.39 0.0043
-
 pH 6.5, temperature not specified in the publication Staphylococcus aureus panosialin A
1.3.1.39 0.0046
-
 pH 6.5, temperature not specified in the publication Staphylococcus aureus panosialin wB
1.3.1.39 0.0053
-
 pH 6.5, temperature not specified in the publication Staphylococcus aureus panosialin B