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Literature summary extracted from

  • Matsuda, T.; Sakaguchi, K.; Hamaguchi, R.; Kobayashi, T.; Abe, E.; Hama, Y.; Hayashi, M.; Honda, D.; Okita, Y.; Sugimoto, S.; Okino, N.; Ito, M.
    Analysis of DELTA12-fatty acid desaturase function revealed that two distinct pathways are active for the synthesis of PUFAs in T. aureum ATCC 34304 (2012), J. Lipid Res., 53, 1210-1222.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.6 expressed in Saccharomyces cerevisiae strain InvSc1 Thraustochytrium aureum
1.14.19.22 expresed in yeast cells Thraustochytrium aureum

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.6 Thraustochytrium aureum
-
-
-
1.14.19.6 Thraustochytrium aureum ATCC 34304
-
-
-
1.14.19.22 Thraustochytrium aureum
-
-
-
1.14.19.22 Thraustochytrium aureum ATCC 3404
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.6 (10Z)-nonadec-10-enoic acid + reduced acceptor + O2
-
 Thraustochytrium aureum (10Z,13Z)-nonadeca-10,13-dienoic acid + acceptor + H2O
-
 ?
1.14.19.6 (10Z)-nonadec-10-enoic acid + reduced acceptor + O2
-
 Thraustochytrium aureum ATCC 3404 (10Z,13Z)-nonadeca-10,13-dienoic acid + acceptor + H2O
-
 ?
1.14.19.6 (10Z)-nonadec-10-enoic acid + reduced acceptor + O2
-
 Thraustochytrium aureum ATCC 34304 (10Z,13Z)-nonadeca-10,13-dienoic acid + acceptor + H2O
-
 ?
1.14.19.6 additional information no activity with myristoleic acid palmitoleic acid, heptadecenoic acid, elaidic acid, linolenic acid, dihomo-gamma-linolenic acid, arachidonic acid, or docosatetraenoic acid Thraustochytrium aureum ?
-
 ?
1.14.19.6 additional information the enzyme has dual specificities of a DELTA12-fatty acid desaturase and a v+3-fatty acid desaturase Thraustochytrium aureum ?
-
 ?
1.14.19.6 additional information no activity with myristoleic acid palmitoleic acid, heptadecenoic acid, elaidic acid, linolenic acid, dihomo-gamma-linolenic acid, arachidonic acid, or docosatetraenoic acid Thraustochytrium aureum ATCC 3404 ?
-
 ?
1.14.19.6 additional information the enzyme has dual specificities of a DELTA12-fatty acid desaturase and a v+3-fatty acid desaturase Thraustochytrium aureum ATCC 3404 ?
-
 ?
1.14.19.6 additional information no activity with myristoleic acid palmitoleic acid, heptadecenoic acid, elaidic acid, linolenic acid, dihomo-gamma-linolenic acid, arachidonic acid, or docosatetraenoic acid Thraustochytrium aureum ATCC 34304 ?
-
 ?
1.14.19.6 additional information the enzyme has dual specificities of a DELTA12-fatty acid desaturase and a v+3-fatty acid desaturase Thraustochytrium aureum ATCC 34304 ?
-
 ?
1.14.19.6 oleic acid + reduced acceptor + O2
-
 Thraustochytrium aureum linoleic acid + acceptor + H2O
-
 ?
1.14.19.6 oleic acid + reduced acceptor + O2
-
 Thraustochytrium aureum ATCC 3404 linoleic acid + acceptor + H2O
-
 ?
1.14.19.6 oleic acid + reduced acceptor + O2
-
 Thraustochytrium aureum ATCC 34304 linoleic acid + acceptor + H2O
-
 ?
1.14.19.22 additional information yeasts transformed with the tauDELTA12des converts endogenous oleic acid into linoleic acid Thraustochytrium aureum ?
-
 ?
1.14.19.22 additional information yeasts transformed with the tauDELTA12des converts endogenous oleic acid into linoleic acid Thraustochytrium aureum ATCC 3404 ?
-
 ?
1.14.19.22 additional information yeasts transformed with the tauDELTA12des converts endogenous oleic acid into linoleic acid Thraustochytrium aureum ATCC 34304 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.6 DELTA12-fatty acid desaturase
-
 Thraustochytrium aureum
1.14.19.6 DELTA12des
-
 Thraustochytrium aureum
1.14.19.22 TauDELTA12des
-
 Thraustochytrium aureum

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.6 additional information does not contain cytochrome b 5 Thraustochytrium aureum

General Information

EC Number General Information Comment Organism
1.14.19.6 malfunction the docosahexaenoic acid content is increased slightly in DELTA12des-disruption mutants Thraustochytrium aureum
1.14.19.22 malfunction the disruption of the tauDELTA12des in Thraustochytrium aureum by homologous recombination results in the accumulation of oleic acid and a decrease in the levels of linoleic acid and its downstream polyunsaturated fatty acids. The transformation of the tauDELTA 12des -disruption mutants with a tauDELTA 12des expression cassette restores the wild-type fatty acid profiles Thraustochytrium aureum