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Literature summary extracted from

  • Keller, M.; Watschinger, K.; Golderer, G.; Maglione, M.; Sarg, B.; Lindner, H.; Werner-Felmayer, G.; Terrinoni, A.; Wanders, R.; Werner, E.
    Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from pyrenedecanal (2010), J. Lipid Res., 51, 1554-1559.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.48 expressed in Escherichia coli Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.48 microsome
-
Mus musculus
-
-
1.2.1.48 microsome
-
Homo sapiens
-
-
1.2.1.48 microsome
-
Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.48 55000
-
2 * 55000, SDS-PAGE Mus musculus
1.2.1.48 55000
-
2 * 55000, SDS-PAGE Homo sapiens
1.2.1.48 55000
-
2 * 55000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.48 cis,cis-9,12-octadecadienal + NAD+ + H2O Mus musculus major substrate cis,cis-9,12-octadecadienoic acid + NADH
-
?
1.2.1.48 cis,cis-9,12-octadecadienal + NAD+ + H2O Homo sapiens major substrate cis,cis-9,12-octadecadienoic acid + NADH
-
?
1.2.1.48 cis,cis-9,12-octadecadienal + NAD+ + H2O Rattus norvegicus major substrate cis,cis-9,12-octadecadienoic acid + NADH
-
?
1.2.1.48 long-chain aldehyde + NAD+ + H2O Mus musculus
-
long-chain acid anion + NADH
-
?
1.2.1.48 long-chain aldehyde + NAD+ + H2O Homo sapiens
-
long-chain carboxylate + NADH
-
?
1.2.1.48 long-chain aldehyde + NAD+ + H2O Rattus norvegicus
-
long-chain carboxylate + NADH
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.48 Homo sapiens
-
-
-
1.2.1.48 Mus musculus
-
-
-
1.2.1.48 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.48 Strep-tag affinity chromatography and AMP-Sepharose column chromatography Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.48 adrenal gland
-
Mus musculus
-
1.2.1.48 cerebellum
-
Mus musculus
-
1.2.1.48 cerebrum
-
Mus musculus
-
1.2.1.48 fibroblast
-
Homo sapiens
-
1.2.1.48 heart low activity Mus musculus
-
1.2.1.48 kidney
-
Mus musculus
-
1.2.1.48 large intestine
-
Mus musculus
-
1.2.1.48 liver
-
Mus musculus
-
1.2.1.48 liver
-
Rattus norvegicus
-
1.2.1.48 lung
-
Mus musculus
-
1.2.1.48 ovary high activity Mus musculus
-
1.2.1.48 skeletal muscle low activity Mus musculus
-
1.2.1.48 spleen
-
Mus musculus
-
1.2.1.48 stomach
-
Mus musculus
-
1.2.1.48 stomach high activity Mus musculus
-
1.2.1.48 subcutaneous adipose tissue
-
Mus musculus
-
1.2.1.48 testis high activity Mus musculus
-
1.2.1.48 visceral fat high activity Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.48 cis,cis-9,12-octadecadienal + NAD+ + H2O major substrate Mus musculus cis,cis-9,12-octadecadienoic acid + NADH
-
?
1.2.1.48 cis,cis-9,12-octadecadienal + NAD+ + H2O major substrate Homo sapiens cis,cis-9,12-octadecadienoic acid + NADH
-
?
1.2.1.48 cis,cis-9,12-octadecadienal + NAD+ + H2O major substrate Rattus norvegicus cis,cis-9,12-octadecadienoic acid + NADH
-
?
1.2.1.48 long-chain aldehyde + NAD+ + H2O
-
Mus musculus long-chain acid anion + NADH
-
?
1.2.1.48 long-chain aldehyde + NAD+ + H2O
-
Homo sapiens long-chain carboxylate + NADH
-
?
1.2.1.48 long-chain aldehyde + NAD+ + H2O
-
Rattus norvegicus long-chain carboxylate + NADH
-
?
1.2.1.48 pyrenedecanal + NAD+ + H2O
-
Mus musculus pyrenedecanoic acid + NADH
-
?
1.2.1.48 pyrenedecanal + NAD+ + H2O
-
Homo sapiens pyrenedecanoic acid + NADH
-
?
1.2.1.48 pyrenedecanal + NAD+ + H2O
-
Rattus norvegicus pyrenedecanoic acid + NADH
-
?

Subunits

EC Number Subunits Comment Organism
1.2.1.48 homodimer 2 * 55000, SDS-PAGE Mus musculus
1.2.1.48 homodimer 2 * 55000, SDS-PAGE Homo sapiens
1.2.1.48 homodimer 2 * 55000, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
1.2.1.48 ALDH3A2
-
Mus musculus
1.2.1.48 ALDH3A2
-
Homo sapiens
1.2.1.48 ALDH3A2
-
Rattus norvegicus
1.2.1.48 fatty aldehyde dehydrogenase
-
Mus musculus
1.2.1.48 fatty aldehyde dehydrogenase
-
Homo sapiens
1.2.1.48 fatty aldehyde dehydrogenase
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.48 NAD+
-
Mus musculus
1.2.1.48 NAD+
-
Homo sapiens
1.2.1.48 NAD+
-
Rattus norvegicus

General Information

EC Number General Information Comment Organism
1.2.1.48 malfunction deficiency in fatty aldehyde dehydrogenase causes the Sjogren Larsson Syndrome, a rare inherited disorder characterized by ichthyosis, spasticity, and mental retardation Homo sapiens