Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Van de Casteele, M.; Demarez, M.; Legrain, C.; Glansdorff, N.; Pierard, A.
    Pathways of arginine biosynthesis in extreme thermophilic archaeo- and eubacteria (1990), J. Gen. Microbiol., 136, 1177-1183.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.5 L-arginine
-
 Saccharolobus solfataricus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.3.3 carbamoyl phosphate + L-ornithine Saccharolobus solfataricus Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized phosphate + L-citrulline
-
 ?
2.1.3.3 carbamoyl phosphate + L-ornithine Saccharolobus solfataricus P1 Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized phosphate + L-citrulline
-
 ?
6.3.4.5 ATP + L-citrulline + L-aspartate Pyrococcus furiosus
-
 AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
 ?
6.3.4.5 ATP + L-citrulline + L-aspartate Saccharolobus solfataricus Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
 ?
6.3.4.5 ATP + L-citrulline + L-aspartate Saccharolobus solfataricus P1 Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.3.3 Pyrococcus furiosus
-
-
-
2.1.3.3 Saccharolobus solfataricus
-
-
-
2.1.3.3 Saccharolobus solfataricus P1
-
-
-
2.3.1.1 Saccharolobus solfataricus
-
-
-
2.3.1.1 Saccharolobus solfataricus P1
-
-
-
2.3.1.35 no activity in Sulfolobus solfataricus
-
-
-
2.7.2.8 Saccharolobus solfataricus
-
-
-
2.7.2.8 Saccharolobus solfataricus P1
-
-
-
3.5.1.16 Saccharolobus solfataricus
-
-
-
3.5.1.16 Saccharolobus solfataricus P1
-
-
-
4.3.2.1 Pyrococcus furiosus
-
-
-
4.3.2.1 Saccharolobus solfataricus
-
-
-
4.3.2.1 Saccharolobus solfataricus P1
-
-
-
6.3.4.5 Pyrococcus furiosus
-
-
-
6.3.4.5 Saccharolobus solfataricus
-
-
-
6.3.4.5 Saccharolobus solfataricus P1
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.3.3 0.12
-
 pH 8.0, 55°C, activity in cell culture in growth medium with 0.2% yeast extract Saccharolobus solfataricus
2.1.3.3 0.255
-
 pH 8.0, 55°C, activity in cell culture in minimal growth medium with 20 mM glucose and 5 mM NH4+ Saccharolobus solfataricus
2.1.3.3 0.43
-
 pH 8.0, 55°C, activity in cell culture in growth medium with 0.5% peptone and 0.1% yeast extract Pyrococcus furiosus
2.3.1.1 0.002
-
 pH 8.0, 70°C, activity in cell culture in growth medium with 0.2% yeast extract Saccharolobus solfataricus
2.3.1.1 0.002
-
 pH 8.0, 70°C, activity in cell culture in minimal growth medium with 20 mM glucose and 5 mM NH4+ Saccharolobus solfataricus
2.7.2.8 0.0008
-
 pH 8.0, 70°C, activity in cell culture in growth medium with 0.2% yeast extract Saccharolobus solfataricus
2.7.2.8 0.003
-
 pH 8.0, 70°C, activity in cell culture in minimal growth medium with 20 mM glucose and 5 mM NH4+ Saccharolobus solfataricus
3.5.1.16 0.13
-
 pH 8.0, 70°C, activity in cell culture in minimal growth medium with 20 mM glucose and 5 mM NH4+ Saccharolobus solfataricus
3.5.1.16 0.15
-
 pH 8.0, 70°C, activity in cell culture in growth medium with 0.2% yeast extract Saccharolobus solfataricus
4.3.2.1 0.003
-
 pH and temperature not specified in the publication, activity in cell culture in growth medium with 0.2% yeast extract Saccharolobus solfataricus
4.3.2.1 0.003
-
 pH and temperature not specified in the publication, activity in cell culture in growth medium with 0.5% peptone and 0.1%yeast extract Pyrococcus furiosus
4.3.2.1 0.006
-
 pH and temperature not specified in the publication, activity in cell culture in minimal growth medium with 20 mM glucose and 5 mM NH4+ Saccharolobus solfataricus
6.3.4.5 0.0002
-
 pH 8.7, 70°C, activity in cell culture in growth medium 0.5% peptone and 0.1% yeast extract Pyrococcus furiosus
6.3.4.5 0.00045
-
 pH 8.7, 70°C, activity in cell culture in growth medium with 0.2% yeast extract Saccharolobus solfataricus
6.3.4.5 0.0007
-
 pH 8.7, 70°C, activity in cell culture in minimal growth medium with 20 mM glucose and 5 mM NH4+ Saccharolobus solfataricus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.3.3 carbamoyl phosphate + L-ornithine
-
 Pyrococcus furiosus phosphate + L-citrulline
-
 ?
2.1.3.3 carbamoyl phosphate + L-ornithine
-
 Saccharolobus solfataricus phosphate + L-citrulline
-
 ?
2.1.3.3 carbamoyl phosphate + L-ornithine Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized Saccharolobus solfataricus phosphate + L-citrulline
-
 ?
2.1.3.3 carbamoyl phosphate + L-ornithine
-
 Saccharolobus solfataricus P1 phosphate + L-citrulline
-
 ?
2.1.3.3 carbamoyl phosphate + L-ornithine Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized Saccharolobus solfataricus P1 phosphate + L-citrulline
-
 ?
2.3.1.1 acetyl-CoA + L-glutamate
-
 Saccharolobus solfataricus CoA + N-acetyl-L-glutamate
-
 ?
2.7.2.8 ATP + N-acetyl-L-glutamate
-
 Saccharolobus solfataricus ADP + N-acetyl-L-glutamyl 5-phosphate
-
 ?
3.5.1.16 N2-acetyl-L-ornithine + H2O
-
 Saccharolobus solfataricus acetate + L-ornithine
-
 ?
3.5.1.16 N2-acetyl-L-ornithine + H2O
-
 Saccharolobus solfataricus P1 acetate + L-ornithine
-
 ?
6.3.4.5 ATP + L-citrulline + L-aspartate
-
 Pyrococcus furiosus AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
 ?
6.3.4.5 ATP + L-citrulline + L-aspartate
-
 Saccharolobus solfataricus AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
 ?
6.3.4.5 ATP + L-citrulline + L-aspartate Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized Saccharolobus solfataricus AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
 ?
6.3.4.5 ATP + L-citrulline + L-aspartate
-
 Saccharolobus solfataricus P1 AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
 ?
6.3.4.5 ATP + L-citrulline + L-aspartate Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized Saccharolobus solfataricus P1 AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.3.3 ornithine carbamoyltransferase
-
 Pyrococcus furiosus
2.1.3.3 ornithine carbamoyltransferase
-
 Saccharolobus solfataricus
2.3.1.1 N-acetyl-glutamate synthase
-
 Saccharolobus solfataricus
2.7.2.8 N-acetyl-glutamate 5-phosphotransferase
-
 Saccharolobus solfataricus
3.5.1.16 acetylornithinase
-
 Saccharolobus solfataricus
4.3.2.1 argininosuccinase
-
 Pyrococcus furiosus
4.3.2.1 argininosuccinase
-
 Saccharolobus solfataricus
6.3.4.5 Argininosuccinate synthetase
-
 Pyrococcus furiosus
6.3.4.5 Argininosuccinate synthetase
-
 Saccharolobus solfataricus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.3.3 55
-
 assay at Pyrococcus furiosus
2.1.3.3 55
-
 assay at Saccharolobus solfataricus
2.3.1.1 70
-
 assay at Saccharolobus solfataricus
2.7.2.8 70
-
 assay at Saccharolobus solfataricus
3.5.1.16 70
-
 assay at Saccharolobus solfataricus
6.3.4.5 70
-
 assay at Pyrococcus furiosus
6.3.4.5 70
-
 assay at Saccharolobus solfataricus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.3.3 8
-
 assay at Pyrococcus furiosus
2.1.3.3 8
-
 assay at Saccharolobus solfataricus
2.3.1.1 8
-
 assay at Saccharolobus solfataricus
2.7.2.8 8
-
 assay at Saccharolobus solfataricus
3.5.1.16 8
-
 assay at Saccharolobus solfataricus
6.3.4.5 8.7
-
 assay at Pyrococcus furiosus
6.3.4.5 8.7
-
 assay at Saccharolobus solfataricus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.3.4.5 0.25
-
 L-arginine pH 8.7, 70°C Saccharolobus solfataricus

Expression

EC Number Organism Comment Expression
2.1.3.3 Pyrococcus furiosus threefold repression of enzyme formation by arginine additional information
2.1.3.3 Saccharolobus solfataricus threefold repression of enzyme formation by arginine additional information
2.3.1.1 Saccharolobus solfataricus no repression by arginine additional information
2.7.2.8 Saccharolobus solfataricus threefold repression of enzyme formation by arginine additional information
3.5.1.16 Saccharolobus solfataricus no repression by arginine additional information
4.3.2.1 Saccharolobus solfataricus threefold repression of enzyme formation by arginine additional information
6.3.4.5 Saccharolobus solfataricus threefold repression of enzyme formation by arginine additional information

General Information

EC Number General Information Comment Organism
2.1.3.3 metabolism Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized Saccharolobus solfataricus
2.3.1.1 metabolism Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized Saccharolobus solfataricus
2.7.2.8 metabolism Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized Saccharolobus solfataricus
3.5.1.16 metabolism Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized Saccharolobus solfataricus
4.3.2.1 metabolism Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized Saccharolobus solfataricus
6.3.4.5 metabolism Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized Saccharolobus solfataricus