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Literature summary extracted from

  • Winkler, D.; Beconi, M.; Toledo-Sherman, L.M.; Prime, M.; Ebneth, A.; Dominguez, C.; Munoz-Sanjuan, I.
    Development of LC/MS/MS, high-throughput enzymatic and cellular assays for the characterization of compounds that inhibit kynurenine monooxygenase (KMO) (2013), J. Biomol. Screen., 18, 879-889.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.13.9 analysis comprehensive panel of biochemical and cell-based assays that use liquid chromatography/tandem mass spectrometry to quantify unlabeled kynurenine and 3-hydroxykynurenine and application to measure kynurenine monooxygenase inhibition in cell and tissue extracts, as well as cellular assays Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.9 4-(3,4-dichlorophenyl)-4-oxobutanoic acid desamino FCE 28833 Homo sapiens
1.14.13.9 Ro 61-8048
-
 Homo sapiens
1.14.13.9 UPF 648
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.13.9 0.014
-
 kynurenine liver lysate, pH 7.4, 25°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.9 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.9 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.9 kynurenine + NADPH + O2
-
 Homo sapiens 3-hydroxy-kynurenine + NADP+ + H2O
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.13.9 0.0000003
-
 pH 7.4, 25°C Homo sapiens UPF 648
1.14.13.9 0.000025
-
 pH 7.4, 25°C Homo sapiens 4-(3,4-dichlorophenyl)-4-oxobutanoic acid
1.14.13.9 0.000035
-
 pH 7.4, 25°C Homo sapiens Ro 61-8048