EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.1.267 | gene Rv2870c, expression of His-tagged enzyme in Escherichia coli strain BL21(DE3) | Mycobacterium tuberculosis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.267 | fosmidomycin | - |
Mycobacterium tuberculosis | |
1.1.1.267 | additional information | development and evaluation of a high-throughput screening spectrometric assay, measuring Dxr activity of Dxr coupled with 1-deoxy-D-xylulose-5-phosphate synthase, Dxs, activity, for simultaneous selection of inhibitors of the enzyme, overview | Mycobacterium tuberculosis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.267 | 0.01 | - |
NADPH | pH 7.5, 25°C, recombinant enzyme | Mycobacterium tuberculosis |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.267 | Co2+ | can partially substitute for Mg2+ or Mn2+ | Mycobacterium tuberculosis | |
1.1.1.267 | Mg2+ | the enzyme essentially requires Mg2+ or Mn2+ | Mycobacterium tuberculosis | |
1.1.1.267 | Mn2+ | the enzyme essentially requires Mg2+ or Mn2+ | Mycobacterium tuberculosis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.267 | 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | Mycobacterium tuberculosis | - |
2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.267 | Mycobacterium tuberculosis | - |
gene Rv2870c | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.267 | recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography to over 90% purity | Mycobacterium tuberculosis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.267 | 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | - |
Mycobacterium tuberculosis | 2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? | |
1.1.1.267 | additional information | development and evaluation of a high-throughput screening assay for simultaneous selection of inhibitors of the enzyme, overview | Mycobacterium tuberculosis | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.267 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | - |
Mycobacterium tuberculosis |
1.1.1.267 | DXR | - |
Mycobacterium tuberculosis |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.267 | 25 | - |
assay at | Mycobacterium tuberculosis |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.267 | 7.5 | - |
assay at | Mycobacterium tuberculosis |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.267 | NADPH | - |
Mycobacterium tuberculosis |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.1.1.267 | 0.000054 | - |
pH 7.5, 25°C, recombinant enzyme | Mycobacterium tuberculosis | fosmidomycin |