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Literature summary extracted from

  • Bertsova, Y.V.; Fadeeva, M.S.; Kostyrko, V.A.; Serebryakova, M.V.; Baykov, A.A.; Bogachev, A.V.
    Alternative pyrimidine biosynthesis protein ApbE is a flavin transferase catalyzing covalent attachment of FMN to a threonine residue in bacterial flavoproteins (2013), J. Biol. Chem., 288, 14276-14286.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.180 expressed in ApbE1-deficient Klebsiella pneumoniae cells Vibrio harveyi

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.180 Mg2+ dependent on Vibrio harveyi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.180 FAD + [protein]-L-threonine Vibrio harveyi
-
 [protein]-FMN-L-threonine + AMP
-
 ?
2.7.1.180 FAD + [protein]-L-threonine Vibrio harveyi R3
-
 [protein]-FMN-L-threonine + AMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.180 Vibrio harveyi
-
-
-
2.7.1.180 Vibrio harveyi R3
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.180 FAD + [protein]-L-threonine
-
 Vibrio harveyi [protein]-FMN-L-threonine + AMP
-
 ?
2.7.1.180 FAD + [protein]-L-threonine
-
 Vibrio harveyi R3 [protein]-FMN-L-threonine + AMP
-
 ?
2.7.1.180 additional information no activity with FMN Vibrio harveyi ?
-
 ?
2.7.1.180 additional information no activity with FMN Vibrio harveyi R3 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.180 apbE
-
 Vibrio harveyi
2.7.1.180 Mg2+-dependent FAD:protein FMN transferase
-
 Vibrio harveyi

General Information

EC Number General Information Comment Organism
2.7.1.180 malfunction enzyme inactivation results in a complete loss of the quinone reductase activity of Na+-translocating NADH:quinone oxidoreductase Vibrio harveyi
2.7.1.180 physiological function ApbE is a modifying enzyme involved in the maturation of flavoproteins. ApbE is the only protein factor required for flavinylation of subunit NqrC in Na+-translocating NADH:quinone oxidoreductase Vibrio harveyi