EC Number | Cloned (Comment) | Organism |
---|---|---|
1.2.1.3 | - |
Homo sapiens |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.2.1.3 | isoform ALDH2, using 100 mM Na-ACES buffer, pH 6.4-6.6, 100 mM guanidine-HCl, 10 mM MgCl2, and 4 mM dithiothreitol and 16-17% (w/v) PEG 6000 | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.3 | 1-(4-chlorophenyl)-3-(1-piperidinyl)-1-propanone | - |
Homo sapiens | |
1.2.1.3 | 3-(1-azepanyl)-1-phenyl-1-propanone | - |
Homo sapiens | |
1.2.1.3 | 3-(dimethylamino)-1-(3-fluoro-4-methoxyphenyl)-1-propanone | - |
Homo sapiens | |
1.2.1.3 | 3-(dimethylamino)-1-(4-ethylphenyl)-1-propanone | - |
Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.3 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.1.3 | ammonium sulfate precipitation, column chromatography, and gel filtration | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.3 | propionaldehyde + NAD+ + H2O | - |
Homo sapiens | propionate + NADH + H+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.2.1.3 | ALD1A1 | isoform | Homo sapiens |
1.2.1.3 | ALDH2 | isoform | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.3 | NAD+ | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.2.1.3 | 0.0022 | - |
isoform ALDH1A1, pH and temperature not specified in the publication | Homo sapiens | 3-(1-azepanyl)-1-phenyl-1-propanone | |
1.2.1.3 | 0.0025 | - |
isoform ALDH1A1, pH and temperature not specified in the publication | Homo sapiens | 3-(dimethylamino)-1-(3-fluoro-4-methoxyphenyl)-1-propanone | |
1.2.1.3 | 0.0054 | - |
isoform ALDH2, pH and temperature not specified in the publication | Homo sapiens | 3-(dimethylamino)-1-(4-ethylphenyl)-1-propanone | |
1.2.1.3 | 0.0064 | - |
isoform ALDH2, pH and temperature not specified in the publication | Homo sapiens | 3-(dimethylamino)-1-(3-fluoro-4-methoxyphenyl)-1-propanone | |
1.2.1.3 | 0.0068 | - |
isoform ALDH1A1, pH and temperature not specified in the publication | Homo sapiens | 1-(4-chlorophenyl)-3-(1-piperidinyl)-1-propanone | |
1.2.1.3 | 0.0079 | - |
isoform ALDH1A1, pH and temperature not specified in the publication | Homo sapiens | 3-(dimethylamino)-1-(4-ethylphenyl)-1-propanone | |
1.2.1.3 | 0.0083 | - |
isoform ALDH2, pH and temperature not specified in the publication | Homo sapiens | 1-(4-chlorophenyl)-3-(1-piperidinyl)-1-propanone | |
1.2.1.3 | 0.0086 | - |
isoform ALDH2, pH and temperature not specified in the publication | Homo sapiens | 3-(1-azepanyl)-1-phenyl-1-propanone |