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Literature summary extracted from

  • Mulrooney, E.F.; Poon, K.K.; McNally, D.J.; Brisson, J.R.; Lam, J.S.
    Biosynthesis of UDP-N-acetyl-L-fucosamine, a precursor to the biosynthesis of lipopolysaccharide in Pseudomonas aeruginosa serotype O11 (2005), J. Biol. Chem., 280, 19535-19542.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.1.3.28 overexpression in Escherichia coli Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.3.28 UDP-2-acetamido-2,6-dideoxy-beta-L-talose Pseudomonas aeruginosa the enzyme is involved in bacterial polysaccharide biosynthesis UDP-N-acetyl-beta-L-fucosamine
-
 ?
5.1.3.28 UDP-2-acetamido-2,6-dideoxy-beta-L-talose Pseudomonas aeruginosa serotype O11 the enzyme is involved in bacterial polysaccharide biosynthesis UDP-N-acetyl-beta-L-fucosamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.367 Pseudomonas aeruginosa
-
-
-
1.1.1.367 Pseudomonas aeruginosa O11
-
-
-
5.1.3.28 Pseudomonas aeruginosa Q9XC59
-
-
5.1.3.28 Pseudomonas aeruginosa serotype O11 Q9XC59
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.1.3.28
-
 Pseudomonas aeruginosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.367 UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose + NADPH + H+
-
 Pseudomonas aeruginosa UDP-2-acetamido-2,6-dideoxy-beta-L-talose + NADP+ + H+ product of enzyme WbjC. WbjC is bifunctional, catalyzing C3 epimerization of UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose, the second intermediate of the pathway followed by reduction at C4 ?
1.1.1.367 UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose + NADPH + H+
-
 Pseudomonas aeruginosa O11 UDP-2-acetamido-2,6-dideoxy-beta-L-talose + NADP+ + H+ product of enzyme WbjC. WbjC is bifunctional, catalyzing C3 epimerization of UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose, the second intermediate of the pathway followed by reduction at C4 ?
5.1.3.28 UDP-2-acetamido-2,6-dideoxy-beta-L-talose the enzyme is involved in bacterial polysaccharide biosynthesis Pseudomonas aeruginosa UDP-N-acetyl-beta-L-fucosamine
-
 ?
5.1.3.28 UDP-2-acetamido-2,6-dideoxy-beta-L-talose UDP-2-acetamido-2,6-dideoxy-beta-L-talose i.e. UDP-N-acetyl-beta-L-pneumosamine. At pH 9.0, the C-2 epimerization reaction catalyzed by WbjD favors the production of UDP-N-acetyl-beta-L-fucosamine over UDP-2-acetamido-2,6-dideoxy-beta-L-talose Pseudomonas aeruginosa UDP-N-acetyl-beta-L-fucosamine
-
 r
5.1.3.28 UDP-2-acetamido-2,6-dideoxy-beta-L-talose the enzyme is involved in bacterial polysaccharide biosynthesis Pseudomonas aeruginosa serotype O11 UDP-N-acetyl-beta-L-fucosamine
-
 ?
5.1.3.28 UDP-2-acetamido-2,6-dideoxy-beta-L-talose UDP-2-acetamido-2,6-dideoxy-beta-L-talose i.e. UDP-N-acetyl-beta-L-pneumosamine. At pH 9.0, the C-2 epimerization reaction catalyzed by WbjD favors the production of UDP-N-acetyl-beta-L-fucosamine over UDP-2-acetamido-2,6-dideoxy-beta-L-talose Pseudomonas aeruginosa serotype O11 UDP-N-acetyl-beta-L-fucosamine
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.367 WbjC
-
 Pseudomonas aeruginosa
5.1.3.28 Cap5G
-
 Pseudomonas aeruginosa
5.1.3.28 WbjD
-
 Pseudomonas aeruginosa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.1.3.28 37
-
 assay at Pseudomonas aeruginosa

General Information

EC Number General Information Comment Organism
5.1.3.28 physiological function the enzyme is involved in bacterial polysaccharide biosynthesis Pseudomonas aeruginosa