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Literature summary extracted from

  • Khanna, M.; Qin, K.N.; Wang, R.W.; Cheng, K.C.
    Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 ?-hydroxysteroid dehydrogenases (1995), J. Biol. Chem., 270, 20162-20168.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.357 overexpression in Escherichia coli Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.357 0.0012
-
 5alpha-dihydrotestosterone apparent Km-value, pH 7.4, 37°C Homo sapiens
1.1.1.357 0.0192
-
 5alpha-dihydrotestosterone apparent Km-value, pH 7.4, 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.357 Homo sapiens P17516
-
-
1.1.1.357 Homo sapiens P42330
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.357 brain
-
 Homo sapiens
-
1.1.1.357 kidney
-
 Homo sapiens
-
1.1.1.357 liver
-
 Homo sapiens
-
1.1.1.357 lung
-
 Homo sapiens
-
1.1.1.357 placenta
-
 Homo sapiens
-
1.1.1.357 testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.357 1-acenaphthenol + NADP+
-
 Homo sapiens acenaphthylen-1(2H)-one + NADPH + H+
-
 ?
1.1.1.357 5alpha-dihydrotestosterone + NADPH + H+
-
 Homo sapiens 5alpha-androstane-3alpha,17beta-diol + NADP+
-
 r
1.1.1.357 androsterone + NADP+
-
 Homo sapiens 5alpha-androstane-3,17-dione + NADPH + H+
-
 ?
1.1.1.357 chenodeoxycholic acid + NADP+
-
 Homo sapiens (5beta,7alpha,8xi)-7-hydroxy-3-oxocholan-24-oic acid + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.357 3alpha-HSD type II Homo sapiens
1.1.1.357 3alpha-HSD type I Homo sapiens