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Literature summary extracted from

  • Engstroem, P.; Nguyen, B.D.; Normark, J.; Nilsson, I.; Bastidas, R.J.; Gylfe, A.; Elofsson, M.; Fields, K.A.; Valdivia, R.H.; Wolf-Watz, H.; Bergstroem, S.
    Mutations in hemG mediate resistance to Salicylidene acylhydrazides: A novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity (2013), J. Bacteriol., 195, 4221-4230.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.3.4 gene hemG, DNA and amino acid sequence determination and analysis Chlamydia trachomatis

Protein Variants

EC Number Protein Variants Comment Organism
1.3.3.4 G58S naturally occuring mutation, suppresses the reduced infectivity caused by treatment with IS-INP0341, an iron-saturated salicylidene acylhydrazide SAH INP0341 Chlamydia trachomatis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.4 protoporphyrinogen IX + 3 O2 Chlamydia trachomatis
-
 protoporphyrin IX + 3 H2O2
-
 ?
1.3.3.4 protoporphyrinogen IX + 3 O2 Chlamydia trachomatis 434/Bu
-
 protoporphyrin IX + 3 H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.4 Chlamydia trachomatis
-
 propagated in HeLa cells, gene hemG
-
1.3.3.4 Chlamydia trachomatis 434/Bu
-
 propagated in HeLa cells, gene hemG
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.4 protoporphyrinogen IX + 3 O2
-
 Chlamydia trachomatis protoporphyrin IX + 3 H2O2
-
 ?
1.3.3.4 protoporphyrinogen IX + 3 O2
-
 Chlamydia trachomatis 434/Bu protoporphyrin IX + 3 H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.3.4 HemG
-
 Chlamydia trachomatis
1.3.3.4 PPO
-
 Chlamydia trachomatis

General Information

EC Number General Information Comment Organism
1.3.3.4 malfunction mutation G58S in hemG suppresses the reduced infectivity caused by treatment with IS-INP0341, an iron-saturated salicylidene acylhydrazide SAH INP0341, which specifically affects Chlamydia trachomatis infectivity with reduced generation of infectious elementary body progeny Chlamydia trachomatis
1.3.3.4 metabolism the enzyme catalyzes the aromatization of protoporphyrinogen IX to protoporphyrin IX, a central step in heme biosynthesis Chlamydia trachomatis
1.3.3.4 physiological function protoporphyrinogen oxidase (HemG) and heme metabolism are important for Chlamydia trachomatis infectivity Chlamydia trachomatis