Literature summary extracted from

Leitsch, D.; Burgess, A.G.; Dunn, L.A.; Krauer, K.G.; Tan, K.; Duchene, M.; Upcroft, P.; Eckmann, L.; Upcroft, J.A.
Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia (2011), J. Antimicrob. Chemother., 66, 1756-1765.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.2.7.1	pyruvate + CoA + oxidized ferredoxin	Giardia intestinalis	-	acetyl-CoA + CO2 + reduced ferredoxin + H+	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.2.7.1	Giardia intestinalis	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.2.7.1	DE52 column chromatography, DEAE-cellulose column chromatography, and Sephadex G25 gel filtration	Giardia intestinalis

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.2.7.1	pyruvate + CoA + oxidized ferredoxin	-	Giardia intestinalis	acetyl-CoA + CO2 + reduced ferredoxin + H+	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.2.7.1	PFOR	-	Giardia intestinalis
1.2.7.1	pyruvate:ferredoxin oxidoreductase	-	Giardia intestinalis

General Information

EC Number	General Information	Comment	Organism
1.2.7.1	malfunction	resistance to metronidazole is associated with enzyme down-regulation	Giardia intestinalis

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Release 2023.1 (January 2023)