Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Forlani, G.; Berlicki, L.; Duo, M.; Dziedziola, G.; Giberti, S.; Bertazzini, M.; Kafarski, P.
    Synthesis and evaluation of effective inhibitors of plant delta1-pyrroline-5-carboxylate reductase (2013), J. Agric. Food Chem., 61, 6792-6798.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.2 2,3-dichlorophenylhydroxymethylenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 2-(2,3-dichlorophenyl)-1-hydroxyethylidenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 2-(2,3-dichlorophenylamino)ethylidenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 2-(2,6-dichlorophenyl)-1-hydroxyethylidenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 2-(2,6-dichlorophenylamino)ethylidenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 2-(3,5-di(trifluoromethyl)phenylamino)ethylidenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 2-(3,5-dichlorophenylamino)ethylidenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 2-(3,5-dimethylphenyl)-1-hydroxyethylidenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 2-(3,5-dimethylphenylamino)ethylidenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 2-(4-benzylphenylamino)ethylidenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 2-(4-chlorophenyl)-1-hydroxyethylidenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 3,5-di(trifluoromethyl)phenylaminomethylenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 3,5-dibromophenylaminomethylenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 3,5-difluorophenylaminomethylenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 3,5-dimethylphenylhydroxymethylenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 3-carbamoylphenylaminomethylenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 3-chlorophenylaminomethylenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 4-benzylphenylaminomethylenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 4-benzylphenylhydroxymethylenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 5,6,7,8-tetrahydro-2-naphthylaminomethylenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 indan-5-ylaminomethylenebisphosphonic acid
-
 Arabidopsis thaliana
1.5.1.2 [[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
-
 Arabidopsis thaliana
1.5.1.2 [[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
-
 Arabidopsis thaliana
1.5.1.2 [[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
-
 Arabidopsis thaliana
1.5.1.2 [[(3,5-dimethylphenyl)amino]methanediyl]bis(phosphonic acid)
-
 Arabidopsis thaliana
1.5.1.2 [[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
-
 Arabidopsis thaliana

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.2 Arabidopsis thaliana
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.1.2 ammonium sulfate precipitation, anion exchange column chromatography, and gel filtration Arabidopsis thaliana

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+
-
 Arabidopsis thaliana L-proline + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.2 DELTA1-pyrroline-5-carboxylate reductase
-
 Arabidopsis thaliana
1.5.1.2 P5C reductase
-
 Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.2 NADH
-
 Arabidopsis thaliana
1.5.1.2 NADPH
-
 Arabidopsis thaliana

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.5.1.2 0.054
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 3,5-dibromophenylaminomethylenebisphosphonic acid
1.5.1.2 0.082
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(3,5-dichlorophenylamino)ethylidenebisphosphonic acid
1.5.1.2 0.134
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana [[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
1.5.1.2 0.325
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 4-benzylphenylhydroxymethylenebisphosphonic acid
1.5.1.2 0.335
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana [[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
1.5.1.2 0.386
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(3,5-dimethylphenylamino)ethylidenebisphosphonic acid
1.5.1.2 0.413
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 3,5-di(trifluoromethyl)phenylaminomethylenebisphosphonic acid
1.5.1.2 0.431
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(2,3-dichlorophenylamino)ethylidenebisphosphonic acid
1.5.1.2 0.45
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana [[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
1.5.1.2 0.463
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(3,5-di(trifluoromethyl)phenylamino)ethylidenebisphosphonic acid
1.5.1.2 0.488
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(2,3-dichlorophenyl)-1-hydroxyethylidenebisphosphonic acid
1.5.1.2 0.488
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(4-benzylphenylamino)ethylidenebisphosphonic acid
1.5.1.2 0.547
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 3-carbamoylphenylaminomethylenebisphosphonic acid
1.5.1.2 0.684
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 5,6,7,8-tetrahydro-2-naphthylaminomethylenebisphosphonic acid
1.5.1.2 0.719
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 3,5-difluorophenylaminomethylenebisphosphonic acid
1.5.1.2 0.763
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(2,6-dichlorophenylamino)ethylidenebisphosphonic acid
1.5.1.2 0.852
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 4-benzylphenylaminomethylenebisphosphonic acid
1.5.1.2 0.97
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana [[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
1.5.1.2 1.187
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2,3-dichlorophenylhydroxymethylenebisphosphonic acid
1.5.1.2 1.245
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana [[(3,5-dimethylphenyl)amino]methanediyl]bis(phosphonic acid)
1.5.1.2 1.409
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 3,5-dimethylphenylhydroxymethylenebisphosphonic acid
1.5.1.2 1.618
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 3-chlorophenylaminomethylenebisphosphonic acid
1.5.1.2 1.639
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(2,6-dichlorophenyl)-1-hydroxyethylidenebisphosphonic acid
1.5.1.2 1.887
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana indan-5-ylaminomethylenebisphosphonic acid
1.5.1.2 1.914
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(3,5-dimethylphenyl)-1-hydroxyethylidenebisphosphonic acid
1.5.1.2 2.071
-
 in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C Arabidopsis thaliana 2-(4-chlorophenyl)-1-hydroxyethylidenebisphosphonic acid